MIR320C1

Summary

MIR320C1 (microRNA 320c-1, HGNC:35248) is a microRNA gene on chromosome 18q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302135 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35248
Approved symbol	MIR320C1
Name	microRNA 320c-1
Location	18q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-320c-1
Ensembl gene	ENSG00000221493
Ensembl biotype	miRNA
Entrez	100302135
RNAcentral	URS0000D55D69 — miRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408566

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408566 — 1 exons

Exon	Start	End
ENSE00001565201	21683510	21683597

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 84.38.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1814 / max 85.6525, expressed in 33 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
169606	0.1814	33

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	84.38	gold quality
kidney	UBERON:0002113	83.30	gold quality
blood	UBERON:0000178	82.38	gold quality
adult mammalian kidney	UBERON:0000082	81.71	gold quality
adrenal tissue	UBERON:0018303	81.64	gold quality
endometrium	UBERON:0001295	79.19	gold quality
bone marrow	UBERON:0002371	78.76	gold quality
monocyte	CL:0000576	75.81	gold quality
placenta	UBERON:0001987	75.76	gold quality
liver	UBERON:0002107	74.69	gold quality
muscle of leg	UBERON:0001383	74.48	gold quality
calcaneal tendon	UBERON:0003701	74.29	gold quality
gastrocnemius	UBERON:0001388	74.21	gold quality
granulocyte	CL:0000094	73.77	gold quality
stomach	UBERON:0000945	73.14	gold quality
lymph node	UBERON:0000029	71.84	gold quality
islet of Langerhans	UBERON:0000006	71.36	gold quality
right lobe of liver	UBERON:0001114	70.93	gold quality
heart left ventricle	UBERON:0002084	70.85	gold quality
heart	UBERON:0000948	70.81	gold quality
amygdala	UBERON:0001876	70.41	gold quality
right atrium auricular region	UBERON:0006631	70.35	gold quality
pancreas	UBERON:0001264	69.65	gold quality
body of stomach	UBERON:0001161	69.29	gold quality
descending thoracic aorta	UBERON:0002345	69.18	gold quality
Ammon’s horn	UBERON:0001954	68.69	gold quality
intestine	UBERON:0000160	68.67	gold quality
transverse colon	UBERON:0001157	68.34	gold quality
colon	UBERON:0001155	68.19	gold quality
left coronary artery	UBERON:0001626	68.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• miR-199a-3p and miR-193b are involved in the senescence of chondrocytes, and miR-320c is involved in the juvenile properties of chondrocytes [miR-199a] (PMID:22674437)
• miR-320c regulates the resistance of pancreatic cancer cells to gemcitabine through SMARCC1. (PMID:23799850)
• miR-320c could inhibit the proliferation, migration and invasion of bladder cancer cells via regulating CDK6. (PMID:25178497)
• The data of this study revealed that miRNA-320c played a crucial role in the carcinoma processes of glioma and might serve as a new prognosis biomarker and therapeutic target of glioma. (PMID:29438779)
• MiR-320c overexpression and CDK6 inhibition attenuated IL-1beta-induced increases in expression of inflammatory products such as iNOS and MMP13 and decreased the expression of anabolic products such as COL2A1 and aggrecan. (PMID:30466085)
• miR-320c suppresses Wnt/beta-catenin signaling pathway by down regulating the expression of beta-catenin. (PMID:31075235)
• MiR-320c prevents the malignant development of cervical cancer by regulating GABRP level. (PMID:32964961)
• The Potential Role of miRNA-19b-3p and miRNA-320c in Patients with Moderate Bronchial Asthma. (PMID:33632094)
• The MiR-320 Family Is Strongly Downregulated in Patients with COVID-19 Induced Severe Respiratory Failure. (PMID:34638691)
• miR-320c Regulates SERPINA1 Expression and Is Induced in Patients With Pulmonary Disease. (PMID:35698951)
• High-glucose induced toxicity in HK-2 cells can be alleviated by inhibition of miRNA-320c. (PMID:35969018)
• Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes. (PMID:38549717)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.