MIR320C2

Summary

MIR320C2 (microRNA 320c-2, HGNC:35387) is a microRNA gene on chromosome 18q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302195 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35387
Approved symbol	MIR320C2
Name	microRNA 320c-2
Location	18q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-320c-2
Ensembl gene	ENSG00000212051
Ensembl biotype	miRNA
Entrez	100302195
RNAcentral	URS0000D5539B — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390762

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390762 — 1 exons

Exon	Start	End
ENSE00001508439	24321686	24321735

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 82.09.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	82.09	gold quality
kidney	UBERON:0002113	80.35	gold quality
stomach	UBERON:0000945	79.68	gold quality
monocyte	CL:0000576	78.47	gold quality
calcaneal tendon	UBERON:0003701	76.74	gold quality
blood	UBERON:0000178	76.44	gold quality
gastrocnemius	UBERON:0001388	73.37	gold quality
prostate gland	UBERON:0002367	71.95	gold quality
body of uterus	UBERON:0009853	71.58	gold quality
right atrium auricular region	UBERON:0006631	70.57	gold quality
tibial artery	UBERON:0007610	70.09	gold quality
putamen	UBERON:0001874	69.70	gold quality
esophagus mucosa	UBERON:0002469	69.66	gold quality
intestine	UBERON:0000160	69.04	gold quality
heart left ventricle	UBERON:0002084	68.80	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.72	gold quality
left adrenal gland	UBERON:0001234	68.46	gold quality
spleen	UBERON:0002106	68.41	gold quality
adrenal gland	UBERON:0002369	68.27	gold quality
skin of abdomen	UBERON:0001416	67.93	gold quality
skin of leg	UBERON:0001511	67.80	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.78	gold quality
right coronary artery	UBERON:0001625	67.70	gold quality
ectocervix	UBERON:0012249	67.52	gold quality
amygdala	UBERON:0001876	67.44	gold quality
left lobe of thyroid gland	UBERON:0001120	67.28	gold quality
ascending aorta	UBERON:0001496	67.18	gold quality
minor salivary gland	UBERON:0001830	67.10	gold quality
colon	UBERON:0001155	67.06	gold quality
omental fat pad	UBERON:0010414	66.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• miR-320c could inhibit the proliferation, migration and invasion of bladder cancer cells via regulating CDK6. (PMID:25178497)
• MiR-320c overexpression and CDK6 inhibition attenuated IL-1beta-induced increases in expression of inflammatory products such as iNOS and MMP13 and decreased the expression of anabolic products such as COL2A1 and aggrecan. (PMID:30466085)
• MiR-320c prevents the malignant development of cervical cancer by regulating GABRP level. (PMID:32964961)
• The Potential Role of miRNA-19b-3p and miRNA-320c in Patients with Moderate Bronchial Asthma. (PMID:33632094)
• miR-320c Regulates SERPINA1 Expression and Is Induced in Patients With Pulmonary Disease. (PMID:35698951)
• Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes. (PMID:38549717)

Cross-species orthologs

0 orthologs

Paralogs (5): MIR320A (ENSG00000208037), MIR320E (ENSG00000211513), MIR320B1 (ENSG00000211543), MIR320D2 (ENSG00000221081), MIR320B2 (ENSG00000221406)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.