MIR320D1

Summary

MIR320D1 (microRNA 320d-1, HGNC:35386) is a microRNA gene on chromosome 13q14.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313896 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35386
Approved symbol	MIR320D1
Name	microRNA 320d-1
Location	13q14.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-320d-1
Ensembl gene	ENSG00000211491
Ensembl biotype	miRNA
Entrez	100313896
RNAcentral	URS0000D561AB — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390157

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390157 — 1 exons

Exon	Start	End
ENSE00001808828	40727828	40727875

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 99.44.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.44	gold quality
skeletal muscle tissue	UBERON:0001134	87.48	gold quality
calcaneal tendon	UBERON:0003701	84.79	gold quality
kidney	UBERON:0002113	80.23	gold quality
corpus callosum	UBERON:0002336	80.00	gold quality
blood	UBERON:0000178	79.51	gold quality
muscle of leg	UBERON:0001383	79.36	gold quality
liver	UBERON:0002107	78.67	gold quality
stomach	UBERON:0000945	77.51	gold quality
leukocyte	CL:0000738	76.93	gold quality
adrenal tissue	UBERON:0018303	76.85	gold quality
monocyte	CL:0000576	76.79	gold quality
gastrocnemius	UBERON:0001388	76.75	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.17	gold quality
heart left ventricle	UBERON:0002084	76.03	gold quality
lymph node	UBERON:0000029	75.24	gold quality
rectum	UBERON:0001052	75.15	gold quality
adult mammalian kidney	UBERON:0000082	74.98	gold quality
islet of Langerhans	UBERON:0000006	74.88	gold quality
tonsil	UBERON:0002372	74.47	gold quality
heart	UBERON:0000948	73.89	gold quality
lung	UBERON:0002048	73.32	gold quality
body of stomach	UBERON:0001161	72.63	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.23	gold quality
body of pancreas	UBERON:0001150	71.83	gold quality
left adrenal gland cortex	UBERON:0035825	71.66	gold quality
right lobe of liver	UBERON:0001114	71.48	gold quality
right atrium auricular region	UBERON:0006631	71.48	gold quality
endometrium	UBERON:0001295	71.47	gold quality
tibial artery	UBERON:0007610	71.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• host-encoded miR-498 and miR-320d regulated HSV-1 induction of KSHV lytic replication by targeting RTA (PMID:23418466)
• these results suggest that low expression of miR-146b-5p and miR-320d may be predictive of compromised responses of a subset of diffuse large B-cell lymphoma patients to treatment with the CHOP regimen (PMID:24931464)
• miR-320d and miR-582 were found to be enriched in apoptotic vascular smooth muscle cells of aortic dissection patients. (PMID:29538087)
• Study found that overexpression of miR320d inhibits the proliferation of diffuse large Bcell lymphoma (DLBCL) cell lines. In addition, miR320d specifically bound to the CDK6 3’UTR. (PMID:31059102)
• Serum exosomal miR-320d is a promising non-invasive diagnostic biomarker for distinguishing metastatic from non-metastatic colorectal cancer. (PMID:31420913)
• Downregulation of serum exosomal miR-320d predicts poor prognosis in hepatocellular carcinoma. (PMID:32125733)
• m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis. (PMID:37738681)
• THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis. (PMID:38963337)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.