MIR320D2

Summary

MIR320D2 (microRNA 320d-2, HGNC:35388) is a microRNA gene on chromosome Xq27.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302169 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35388
Approved symbol	MIR320D2
Name	microRNA 320d-2
Location	Xq27.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-320d-2
Ensembl gene	ENSG00000221081
Ensembl biotype	miRNA
Entrez	100302169
RNAcentral	URS0000D549F0 — miRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408154

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408154 — 1 exons

Exon	Start	End
ENSE00001808871	140926172	140926219

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 88.15.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.15	gold quality
blood	UBERON:0000178	84.90	gold quality
stomach	UBERON:0000945	76.59	gold quality
esophagus mucosa	UBERON:0002469	69.18	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.06	gold quality
anterior cingulate cortex	UBERON:0009835	64.12	gold quality
colon	UBERON:0001155	53.91	gold quality
testis	UBERON:0000473	50.68	gold quality
left testis	UBERON:0004533	47.88	gold quality
corpus callosum	UBERON:0002336	40.29	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• miR-320d and miR-582 were found to be enriched in apoptotic vascular smooth muscle cells of aortic dissection patients. (PMID:29538087)
• Study found that overexpression of miR320d inhibits the proliferation of diffuse large Bcell lymphoma (DLBCL) cell lines. In addition, miR320d specifically bound to the CDK6 3’UTR. (PMID:31059102)
• Serum exosomal miR-320d is a promising non-invasive diagnostic biomarker for distinguishing metastatic from non-metastatic colorectal cancer. (PMID:31420913)
• Downregulation of serum exosomal miR-320d predicts poor prognosis in hepatocellular carcinoma. (PMID:32125733)
• THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis. (PMID:38963337)

Cross-species orthologs

0 orthologs

Paralogs (5): MIR320A (ENSG00000208037), MIR320E (ENSG00000211513), MIR320B1 (ENSG00000211543), MIR320C2 (ENSG00000212051), MIR320B2 (ENSG00000221406)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.