MIR320E

Summary

MIR320E (microRNA 320e, HGNC:38230) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422913 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38230
Approved symbol	MIR320E
Name	microRNA 320e
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-320e
Ensembl gene	ENSG00000211513
Ensembl biotype	miRNA
Entrez	100422913
RNAcentral	URS0000D55CCB — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390179

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390179 — 1 exons

Exon	Start	End
ENSE00001507606	46709293	46709345

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 84.39.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	84.39	gold quality
adrenal tissue	UBERON:0018303	81.40	gold quality
blood	UBERON:0000178	81.19	gold quality
vermiform appendix	UBERON:0001154	80.95	gold quality
bone marrow	UBERON:0002371	77.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.72	gold quality
muscle of leg	UBERON:0001383	76.64	gold quality
placenta	UBERON:0001987	76.41	gold quality
monocyte	CL:0000576	75.57	gold quality
leukocyte	CL:0000738	75.47	gold quality
gastrocnemius	UBERON:0001388	75.24	gold quality
apex of heart	UBERON:0002098	73.74	gold quality
heart left ventricle	UBERON:0002084	73.69	gold quality
calcaneal tendon	UBERON:0003701	73.60	gold quality
pancreas	UBERON:0001264	72.91	gold quality
liver	UBERON:0002107	72.14	gold quality
body of pancreas	UBERON:0001150	71.78	gold quality
rectum	UBERON:0001052	71.23	gold quality
anterior cingulate cortex	UBERON:0009835	71.19	gold quality
adult mammalian kidney	UBERON:0000082	71.09	gold quality
tibial artery	UBERON:0007610	71.05	gold quality
adrenal gland	UBERON:0002369	71.02	gold quality
smooth muscle tissue	UBERON:0001135	70.94	gold quality
endometrium	UBERON:0001295	70.93	gold quality
substantia nigra	UBERON:0002038	70.50	gold quality
lung	UBERON:0002048	70.47	gold quality
right lobe of liver	UBERON:0001114	70.24	gold quality
stomach	UBERON:0000945	70.23	gold quality
amygdala	UBERON:0001876	70.11	gold quality
left adrenal gland cortex	UBERON:0035825	70.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• systematic biomarker discovery and validation approach identified miR-320e to be a novel prognostic biomarker that is associated with adverse clinical outcome in stage III CRC patients treated with 5-FU-based adjuvant chemotherapy (PMID:26035698)
• Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1. (PMID:35513391)

Cross-species orthologs

0 orthologs

Paralogs (5): MIR320A (ENSG00000208037), MIR320B1 (ENSG00000211543), MIR320C2 (ENSG00000212051), MIR320D2 (ENSG00000221081), MIR320B2 (ENSG00000221406)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.