MIR323B

Summary

MIR323B (microRNA 323b, HGNC:38349) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574410 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38349
Approved symbol	MIR323B
Name	microRNA 323b
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-323b, hsa-mir-453
Ensembl gene	ENSG00000208004
Ensembl biotype	miRNA
Entrez	574410
RNAcentral	URS000075B679 — miRNA, 82 nt, 15 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385269

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385269 — 1 exons

Exon	Start	End
ENSE00001500275	101056219	101056300

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 97.08.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	97.08	gold quality
stomach	UBERON:0000945	80.83	gold quality
adrenal gland	UBERON:0002369	79.96	gold quality
placenta	UBERON:0001987	78.64	gold quality
prostate gland	UBERON:0002367	77.68	gold quality
blood	UBERON:0000178	77.49	gold quality
intestine	UBERON:0000160	76.19	gold quality
lung	UBERON:0002048	75.09	gold quality
right adrenal gland cortex	UBERON:0035827	74.60	gold quality
islet of Langerhans	UBERON:0000006	74.57	gold quality
heart	UBERON:0000948	73.15	gold quality
adult mammalian kidney	UBERON:0000082	73.05	gold quality
gastrocnemius	UBERON:0001388	71.88	gold quality
colon	UBERON:0001155	71.41	gold quality
adipose tissue	UBERON:0001013	70.95	gold quality
right frontal lobe	UBERON:0002810	70.85	gold quality
monocyte	CL:0000576	70.36	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.10	gold quality
omental fat pad	UBERON:0010414	69.18	gold quality
body of pancreas	UBERON:0001150	68.99	gold quality
liver	UBERON:0002107	68.98	gold quality
body of stomach	UBERON:0001161	68.72	gold quality
left adrenal gland	UBERON:0001234	68.02	gold quality
putamen	UBERON:0001874	68.00	gold quality
left ovary	UBERON:0002119	67.89	gold quality
apex of heart	UBERON:0002098	67.04	gold quality
left adrenal gland cortex	UBERON:0035825	66.94	gold quality
skin of leg	UBERON:0001511	66.93	gold quality
ascending aorta	UBERON:0001496	66.43	gold quality
anterior cingulate cortex	UBERON:0009835	66.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• The polymorphism of miRNA-323b was significantly associated with persistence of hepatitis B virus by the enhancement of hepatitis B virus replication (P = 0.021). (PMID:24341744)
• circulating hsa-miR-323b-5p could be a promising serum biomarker for the diagnosis of critical limb ischemia in type 2 diabetic patients. (PMID:30305681)
• There is no significant correlation between rs56103835 polymorphism and the incidence and progression of breast cancer in the population of Isfahan, Iran. (PMID:30706682)
• MiR-323-3p Targeting Transmembrane Protein with EGF-Like and 2 Follistatin Domain (TMEFF2) Inhibits Human Lung Cancer A549 Cell Apoptosis by Regulation of AKT and ERK Signaling Pathways. (PMID:32009129)
• Identification of novel factors that affect the onset of idiopathic chronic pancreatitis: The role for microRNA-323b-5p. (PMID:36219542)

Cross-species orthologs

0 orthologs

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR1185-1 (ENSG00000221525), MIR1185-2 (ENSG00000221614), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.