MIR329-1

Summary

MIR329-1 (microRNA 329-1, HGNC:32050) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574408 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32050
Approved symbol	MIR329-1
Name	microRNA 329-1
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-329-1
Ensembl gene	ENSG00000207761
Ensembl biotype	miRNA
Entrez	574408
RNAcentral	URS0000668584 — miRNA, 80 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385028

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385028 — 1 exons

Exon	Start	End
ENSE00001500035	101026785	101026864

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 74.32.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	74.32	gold quality
stomach	UBERON:0000945	72.64	gold quality
right atrium auricular region	UBERON:0006631	71.11	gold quality
colon	UBERON:0001155	69.62	gold quality
urinary bladder	UBERON:0001255	66.36	gold quality
skin of abdomen	UBERON:0001416	62.87	gold quality
cerebellar hemisphere	UBERON:0002245	60.84	gold quality
left ovary	UBERON:0002119	60.64	gold quality
lung	UBERON:0002048	59.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• MiR-329 may inhibit cell proliferation in human glioma cells through regulating E2F1-mediated suppression of Akt pathway. (PMID:23866847)
• Identified a novel negative regulator of angiogenesis, microRNA 329 (miR-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo. (PMID:23878390)
• Data indicate that overexpression of KDM1A partially reversed the tumor suppressive effects of miR-329 in neuroblastoma cells. (PMID:24316513)
• Data show that in arterial endothelial cells, inhibition of miR-329, miR-487b, and miR-495 all led to increased cell proliferation by approximately 20%, 50%, and 35%, respectively, but inhibition of miR-494 did not affect endothelial cell proliferation. (PMID:25085941)
• Stable ectopic expression of Wnt-7b in OSCC cells overexpressing miR329 or miR410 restored proliferation and invasion capabilities abolished by these miRNA (PMID:25351956)
• Report feedback loop between PTTG1 targeting miRNAs,including mir329, PTTG1 and p53 that promotes pituitary tumorigenesis. (PMID:26320179)
• Evidence for a novel role for miR-362-3p and miR-329 as tumor suppressors. (PMID:26337669)
• Data show that knockdown of bromodomain containing 4 (BRD4) reversed the effect of microRNA miR-329 inhibition. (PMID:26456956)
• Data indicate GRB2 as a direct target of miR-329 in pancreatic cancer cells, and expression of GRB2 was inversely correlated with miR-329 expression in pancreatic cancer patients. (PMID:26885689)
• Results indicate that miR-329 played a pivotal role in lung cancer through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic MET. (PMID:26909600)
• miR-329 also suppresses wound-healing and migration ability of osteosarcoma cells and inhibits tumorigenicity in vivo. Rab10 was identified as a target of miR-329 in osteosarcoma and mediates its biofunction (PMID:27487475)
• Results show that miRNA-329 was down-regulated in the gastric cancer (GC) cells and tissues. The up-regulation of miRNA-329 might inhibit the proliferation and promote the apoptosis of GC cells via targeting KDM1A. (PMID:29130516)
• ZFAS1 could serve as an oncogene in the tumorigenesis of bladder cancer, and discovered the functional regulatory network of ZFAS1 sponging miR-329. (PMID:29653362)
• MiR-329 inhibits BDC progression through translational repression of LAMB3. (PMID:30887508)
• The tumor suppressor role played by miR-329 in melanoma might be achieved through inhibiting the oncogenic beta-catenin pathway activation by downregulating HMGB2 expression. (PMID:31219186)
• Overexpression of XIST facilitates cell proliferation, invasion and suppresses cell apoptosis by reducing radio-sensitivity of glioma cells via miR-329-3p/CREB1 axis. (PMID:32271437)
• LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis. (PMID:32329857)
• LncRNA-PCAT1 maintains characteristics of dermal papilla cells and promotes hair follicle regeneration by regulating miR-329/Wnt10b axis. (PMID:32339605)
• MiR-329-3p inhibits hepatocellular carcinoma cell proliferation and migration through USP22-Wnt/beta-Catenin pathway. (PMID:33090397)
• LncRNA-TMPO-AS1 promotes apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1. (PMID:33215415)
• Exosomal lncRNA PCAT1 Promotes Tumor Circulating Cell-Mediated Colorectal Cancer Liver Metastasis by Regulating the Activity of the miR-329-3p/Netrin-1-CD146 Complex. (PMID:36093435)
• miRNA-329-3p suppresses proliferation and metastasis of endometrial carcinoma through downregulating E2F1. (PMID:37789781)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.