MIR329-2

Summary

MIR329-2 (microRNA 329-2, HGNC:32051) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574409 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32051
Approved symbol	MIR329-2
Name	microRNA 329-2
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-329-2
Ensembl gene	ENSG00000207762
Ensembl biotype	miRNA
Entrez	574409
RNAcentral	URS000075D4D9 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385029

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385029 — 1 exons

Exon	Start	End
ENSE00001500036	101027100	101027183

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 96.82.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.82	gold quality
stomach	UBERON:0000945	85.12	gold quality
lung	UBERON:0002048	84.03	gold quality
kidney	UBERON:0002113	82.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.57	gold quality
calcaneal tendon	UBERON:0003701	77.67	gold quality
intestine	UBERON:0000160	77.48	gold quality
monocyte	CL:0000576	76.75	gold quality
heart	UBERON:0000948	75.64	gold quality
fundus of stomach	UBERON:0001160	75.38	gold quality
gastrocnemius	UBERON:0001388	75.06	gold quality
blood	UBERON:0000178	72.51	gold quality
Ammon’s horn	UBERON:0001954	70.69	gold quality
colon	UBERON:0001155	70.43	gold quality
body of stomach	UBERON:0001161	69.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.22	gold quality
prefrontal cortex	UBERON:0000451	67.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.53	gold quality
left adrenal gland cortex	UBERON:0035825	67.44	gold quality
omental fat pad	UBERON:0010414	66.92	gold quality
right frontal lobe	UBERON:0002810	66.67	gold quality
putamen	UBERON:0001874	66.45	gold quality
transverse colon	UBERON:0001157	66.07	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.57	gold quality
tibial nerve	UBERON:0001323	65.39	gold quality
right atrium auricular region	UBERON:0006631	65.32	gold quality
esophagus mucosa	UBERON:0002469	65.27	gold quality
hypothalamus	UBERON:0001898	65.21	gold quality
right adrenal gland	UBERON:0001233	65.05	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Report feedback loop between PTTG1 targeting miRNAs,including mir329, PTTG1 and p53 that promotes pituitary tumorigenesis. (PMID:26320179)
• Evidence for a novel role for miR-362-3p and miR-329 as tumor suppressors. (PMID:26337669)
• Data show that knockdown of bromodomain containing 4 (BRD4) reversed the effect of microRNA miR-329 inhibition. (PMID:26456956)
• Data indicate GRB2 as a direct target of miR-329 in pancreatic cancer cells, and expression of GRB2 was inversely correlated with miR-329 expression in pancreatic cancer patients. (PMID:26885689)
• Results indicate that miR-329 played a pivotal role in lung cancer through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic MET. (PMID:26909600)
• Results show that miRNA-329 was down-regulated in the gastric cancer (GC) cells and tissues. The up-regulation of miRNA-329 might inhibit the proliferation and promote the apoptosis of GC cells via targeting KDM1A. (PMID:29130516)
• ZFAS1 could serve as an oncogene in the tumorigenesis of bladder cancer, and discovered the functional regulatory network of ZFAS1 sponging miR-329. (PMID:29653362)
• The tumor suppressor role played by miR-329 in melanoma might be achieved through inhibiting the oncogenic beta-catenin pathway activation by downregulating HMGB2 expression. (PMID:31219186)
• Exosomal lncRNA PCAT1 Promotes Tumor Circulating Cell-Mediated Colorectal Cancer Liver Metastasis by Regulating the Activity of the miR-329-3p/Netrin-1-CD146 Complex. (PMID:36093435)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.