MIR337

Summary

MIR337 (microRNA 337, HGNC:31774) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442905 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31774
Approved symbol	MIR337
Name	microRNA 337
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-337
Ensembl gene	ENSG00000199151
Ensembl biotype	miRNA
OMIM	620408
Entrez	442905
RNAcentral	URS000075CFEA — miRNA, 93 nt, 21 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362281

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362281 — 1 exons

Exon	Start	End
ENSE00001437044	100874493	100874585

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 80.67.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.67	gold quality
heart left ventricle	UBERON:0002084	75.82	gold quality
adult mammalian kidney	UBERON:0000082	75.11	gold quality
body of stomach	UBERON:0001161	74.10	gold quality
transverse colon	UBERON:0001157	73.37	gold quality
stomach	UBERON:0000945	73.26	gold quality
sural nerve	UBERON:0015488	72.66	gold quality
left ovary	UBERON:0002119	72.35	gold quality
right adrenal gland	UBERON:0001233	70.69	gold quality
islet of Langerhans	UBERON:0000006	70.04	gold quality
right atrium auricular region	UBERON:0006631	69.98	gold quality
myometrium	UBERON:0001296	69.39	gold quality
right ovary	UBERON:0002118	69.29	gold quality
tibial artery	UBERON:0007610	69.06	gold quality
ascending aorta	UBERON:0001496	68.96	gold quality
vagina	UBERON:0000996	68.77	gold quality
body of pancreas	UBERON:0001150	68.77	gold quality
endometrium	UBERON:0001295	68.71	gold quality
right adrenal gland cortex	UBERON:0035827	68.60	gold quality
colon	UBERON:0001155	68.47	gold quality
left adrenal gland cortex	UBERON:0035825	68.35	gold quality
thoracic aorta	UBERON:0001515	68.34	gold quality
left adrenal gland	UBERON:0001234	68.04	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.97	gold quality
Ammon’s horn	UBERON:0001954	67.90	gold quality
substantia nigra	UBERON:0002038	67.67	gold quality
putamen	UBERON:0001874	67.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.03	gold quality
esophagus mucosa	UBERON:0002469	66.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 32)

• The identification of a miR-337-3p as a modulator of cellular response to taxanes, and STAT3 and RAP1A as regulatory targets which mediate that response. (PMID:22723956)
• A polymorphism in the 3’-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia. (PMID:23065518)
• Findings indicate that hsa-miR-337-3p plays a role in the reduction of gastric cancer cell invasion capacity. (PMID:24422944)
• HOXB7 was over-expressed and miR-337 was minimally expressed in pancreatic ductal adenocarcinoma (PMID:24641834)
• hsa-mir-337-3p is more frequently down-regulated in endometrial cancers from whites compared to blacks. (PMID:25174797)
• MiR-337 targets HOXB7 and effects significant suppression of pancreatic ductal adenocarcinoma (PDAC) cell proliferation and invasion. (PMID:25183455)
• Data indicate that miR-337-3p directly binds the MMP-14 promoter to repress its transcription, thus suppressing the progression of NB. (PMID:26084291)
• the current study observed overexpression of miR-337 in EC tissues. As a target of miR-337, PTEN regulates expression at the transcriptional level and the inhibition of PTEN promotes the proliferation of EC cells in vitro. (PMID:27082228)
• miR-337-3p directly binds to the MMP-14 promoter to repress MZF1-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer (PMID:27259238)
• MiR-337 could target STAT3 to regulate the occurrence and development of melanoma. (PMID:28498028)
• MiR-337-3p regulated Osteoarthritis (OA) chondrocytes proliferation through PTEN/AKT axis and thus involved in OA. (PMID:28931211)
• MicroRNA-337 is up-regulated in osteosarcoma tissues. (PMID:30229817)
• Collectively, these data suggested the tumor suppressive role of miR-337-3p in ccRCC. MiR-337-3p suppressed cell proliferation and metastasis in lear cell renal cell carcinoma partially via targeting Capn4. (PMID:30452399)
• MiR-337-3p was discovered to be decreased in cervical cancer, and miR-337-3p up-regulation may inhibit the proliferation, migration and invasion and promote the apoptosis of cervical cancer cells via down-regulating Rap1A. (PMID:30883336)
• LncRNA CRNDE promotes hepatocellular carcinoma progression by upregulating SIX1 through modulating miR-337-3p. (PMID:31099050)
• miR-337 expression is downregulated in both Cutaneous T-cell lymphoma (CTCL) tumors and cell lines. Transfection with the miR-337 mimic resulted in decreased proliferation and increased apoptotic levels in CTCL cells. miR-337 targets the 3’-UTR of STAT3 for silencing. The study indicates that the miR-337-STAT3 axis inhibits the proliferation of malignant T cells. (PMID:31213131)
• Expression of miR-337-3p is down-regulated in epithelial ovarian cancer (EOC) tissues and low expression of miR-337-3p is correlated with advanced pathological grade for patients. PIK3CA and PIK3CB were revealed to be direct targets of miR-337-3p. In vivo investigation confirmed that miR-337-3p is a tumor suppressor that control expression of PIK3CA and PIK3CB encoded protein: p110alpha and p110beta. (PMID:31629932)
• miR3373p inhibits gastric tumor metastasis by targeting ARHGAP10. (PMID:31789419)
• Circ_0000388 Exerts Oncogenic Function in Cervical Cancer Cells by Regulating miR-337-3p/TCF12 Axis. (PMID:32119786)
• MiR-337-3p Promotes Adipocyte Browning by Inhibiting TWIST1. (PMID:32340411)
• The lncRNA XIST promotes proliferation, migration and invasion of gastric cancer cells by targeting miR-337. (PMID:32830093)
• Long noncoding RNA TTTY15 promotes growth and metastasis of esophageal squamous cell carcinoma by sponging microRNA-337-3p to upregulate the expression of JAK2. (PMID:32868648)
• hsa_circ_0006916 promotes hepatocellular carcinoma progression by activating the miR-337-3p/STAT3 axis. (PMID:33292166)
• Involvement of miR-337 in high glucose-suppressed osteogenic differentiation in bone marrow mesenchymal stem cells via negative regulation of Rap1A. (PMID:33748908)
• MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice. (PMID:33775647)
• Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis. (PMID:33896365)
• Circ-SPG11 knockdown hampers IL-1beta-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5. (PMID:34140036)
• Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p. (PMID:34424826)
• MiR-337-3p suppresses migration and invasion of breast cancer cells by downregulating ESRP1. (PMID:34481218)
• MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway. (PMID:34697729)
• MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity. (PMID:34912331)
• Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3. (PMID:36426731)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir337	ENSMUSG00000065526
rattus_norvegicus	Mir337	ENSRNOG00000035527

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.