MIR345

Summary

MIR345 (microRNA 345, HGNC:31779) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442910 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31779
Approved symbol	MIR345
Name	microRNA 345
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-345
Ensembl gene	ENSG00000198984
Ensembl biotype	miRNA
Entrez	442910
RNAcentral	URS000075E1CD — miRNA, 98 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362114

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362114 — 1 exons

Exon	Start	End
ENSE00001436877	100307859	100307956

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 78.61.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.61	gold quality
muscle of leg	UBERON:0001383	77.45	gold quality
blood	UBERON:0000178	75.78	gold quality
gastrocnemius	UBERON:0001388	75.11	gold quality
heart left ventricle	UBERON:0002084	74.50	gold quality
endometrium	UBERON:0001295	74.37	gold quality
lung	UBERON:0002048	74.33	gold quality
body of pancreas	UBERON:0001150	73.87	gold quality
adult mammalian kidney	UBERON:0000082	73.70	gold quality
islet of Langerhans	UBERON:0000006	72.98	gold quality
adrenal tissue	UBERON:0018303	71.63	gold quality
calcaneal tendon	UBERON:0003701	71.14	gold quality
heart	UBERON:0000948	70.71	gold quality
tibial artery	UBERON:0007610	69.88	gold quality
stomach	UBERON:0000945	69.74	gold quality
urinary bladder	UBERON:0001255	69.35	gold quality
ascending aorta	UBERON:0001496	69.00	gold quality
upper lobe of left lung	UBERON:0008952	68.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.50	gold quality
right lobe of thyroid gland	UBERON:0001119	68.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.38	gold quality
myometrium	UBERON:0001296	68.16	gold quality
body of stomach	UBERON:0001161	68.15	gold quality
left adrenal gland	UBERON:0001234	67.95	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.48	gold quality
left coronary artery	UBERON:0001626	67.42	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.09	gold quality
putamen	UBERON:0001874	67.07	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• Down regulation of MicroRNA 345 is associated with colorectal cancer. (PMID:21665895)
• miR-345 in whole blood as a potential biomarker for clinical outcome in in non-KRAS mutant colorectal cancer patients. (PMID:24940606)
• MiR-345 downregulation confers apoptosis resistance to PC cells. (PMID:26247574)
• Circulating serum miR-345 correlates with unfavorable preoperative chemoradiotherapy response and poor locoregional control in locally advanced rectal cancer. (PMID:27572313)
• let-7b-5p and miR-345-5p as promising blood-derived disease biomarkers in Multiple Sclerosis. (PMID:27694855)
• MiR-345 was found to be decreased in gastric cancer (GC) tissues and cell lines and associated with adverse clinical features and unfavorable prognosis of GC patients. Functionally, miR-345 inhibited the metastasis of GC cells both in vitro and in vivo. miR-345 was found to inhibit epithelial-mesenchymal transition of GC cells. (PMID:29048674)
• results set the stage for a further investigation on the potential application of circulating miR-345-5p as a biomarker for prostate cancer diagnosis and therapeutic response (PMID:29748958)
• Our study demonstrated that TMS reduced gefitinib resistance in NSCLCs via suppression of the MAPK/Akt/Bcl-2 pathway by upregulation of miR-345/498. (PMID:30701693)
• MiR-345-5p was a tumor-suppressive miRNA in pancreatic cancer progression by targeting CCL8. (PMID:30841468)
• MicroRNA-345 suppresses cell invasion and migration in non-small cell lung cancer by directly targeting YAP1. (PMID:30964169)
• MiR-345-3p prevented oxLDL-induced apoptosis and inflammation through the TAK1/p38/NF-kappaB pathway via targeting TRAF6 (PMID:31825793)
• Osteoporosis genome-wide association study variant c.3781 C>A is regulated by a novel anti-osteogenic factor miR-345-5p. (PMID:31883164)
• miR-345 inhibits migration and stem-like cell phenotype in gastric cancer via inactivation of Rac1 by targeting EPS8. (PMID:32147678)
• LncRNA DANCR affected cell growth, EMT and angiogenesis by sponging miR-345-5p through modulating Twist1 in cholangiocarcinoma. (PMID:32196584)
• MicroRNA 345 (miR345) regulates KISS1-E-cadherin functional interaction in breast cancer brain metastases. (PMID:32246957)
• MicroRNA-345 functions as a tumor suppressor via targeting ZEB2 in oral squamous cell carcinoma. (PMID:32445972)
• Long non-coding RNA RACGAP1P promotes breast cancer invasion and metastasis via miR-345-5p/RACGAP1-mediated mitochondrial fission. (PMID:33252198)
• Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis. (PMID:34231101)
• Upregulation of miR-345-5p suppresses cell growth of lung adenocarcinoma by regulating ras homolog family member A (RhoA) and Rho/Rho associated protein kinase (Rho/ROCK) pathway. (PMID:34748526)
• The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells. (PMID:34922339)
• miR-345-5p curbs hepatic stellate cell activation and liver fibrosis progression by suppressing hypoxia-inducible factor-1alpha expression. (PMID:36126797)
• cDCBLD2 mediates sorafenib resistance in hepatocellular carcinoma by sponging miR-345-5p binding to the TOP2A coding sequence. (PMID:37781045)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir345	ENSMUSG00000065429
rattus_norvegicus	Mir345	ENSRNOG00000035618

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.