MIR346

Summary

MIR346 (microRNA 346, HGNC:31780) is a microRNA gene on chromosome 10q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442911 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31780
Approved symbol	MIR346
Name	microRNA 346
Location	10q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-346
Ensembl gene	ENSG00000199104
Ensembl biotype	miRNA
OMIM	611190
Entrez	442911
RNAcentral	URS000075B886 — miRNA, 95 nt, 28 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362234

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362234 — 1 exons

Exon	Start	End
ENSE00001436997	86264694	86264788

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 80.60.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.60	gold quality
stomach	UBERON:0000945	79.59	gold quality
body of pancreas	UBERON:0001150	69.27	gold quality
substantia nigra	UBERON:0002038	69.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.71	gold quality
nucleus accumbens	UBERON:0001882	68.41	gold quality
esophagus mucosa	UBERON:0002469	67.24	gold quality
left lobe of thyroid gland	UBERON:0001120	65.95	gold quality
prefrontal cortex	UBERON:0000451	65.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.93	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.64	gold quality
Ammon’s horn	UBERON:0001954	64.59	gold quality
caudate nucleus	UBERON:0001873	64.39	gold quality
thyroid gland	UBERON:0002046	64.36	gold quality
cerebellar hemisphere	UBERON:0002245	64.28	gold quality
skin of abdomen	UBERON:0001416	64.15	gold quality
hypothalamus	UBERON:0001898	64.04	gold quality
liver	UBERON:0002107	63.95	gold quality
putamen	UBERON:0001874	63.93	gold quality
anterior cingulate cortex	UBERON:0009835	63.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.84	gold quality
right frontal lobe	UBERON:0002810	60.93	gold quality
lung	UBERON:0002048	59.16	gold quality
corpus callosum	UBERON:0002336	58.56	gold quality
left adrenal gland cortex	UBERON:0035825	57.65	gold quality
prostate gland	UBERON:0002367	55.08	gold quality
tibial nerve	UBERON:0001323	54.22	gold quality
left testis	UBERON:0004533	42.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 31)

• miR-346 indirectly regulated IL-18 release by indirectly inhibiting LPS-induced Bruton’s tyrosine kinase expression in LPS-activated rheumatoid arthritis fibroblast-like synoviocytes (PMID:19342689)
• These results indicate that miR-346 controls TNF-alpha synthesis by regulating TTP expression. (PMID:21611196)
• The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. (PMID:22002058)
• Function of microRNA-346 and its roles in human diseases. (PMID:22838046)
• High MicroRNA-346 expression is associated with mucosal inflammation and colitis development. (PMID:25192497)
• A negative correlation between levels of miR-346 and percentages of CD4(+)CXCR5(+) T cells was confirmed in Graves’ disease (PMID:25666935)
• Ectopic expression of miR-346 promoted the A431 cell proliferation. (PMID:26408183)
• MiR-346 depends on GRSF1 to upregulate another target gene. (PMID:26507454)
• GRSF1 participated in the regulation of AGO2 by miR-346, and the middle sequence of miR-346 was vital for the synergy effect of miR-346 and GRSF1. (PMID:26518874)
• miR-346 promotes migration and invasion of nasopharyngeal carcinoma cells via targeting BRMS1. (PMID:27501413)
• miR-346 and miR-582-3p regulate EG-VEGF-induced trophoblast invasion through repressing MMP 2 and MMP 9, and may become novel diagnostic biomarkers or therapeutic targets for EG-VEGF-related obstetric disorders. (c) 2016 BioFactors, 43(2):210-219, 2017. (PMID:27619846)
• miR-346 may function as an oncogenic miRNA and mediate chemosensitivity to docetaxel through targeting SRCIN1 in breast cancer (PMID:27913185)
• MiR-346 at diagnosis and cessation, and TRAb at cessation could serve as predictive factors for Graves’ Disease relapse within 1 year after drug withdrawal (PMID:28192819)
• Results show that aberrant miR-346 and miR-582 expression profiles in maternal plasma, fetal cord plasma and placenta samples were shown to be associated with preeclampsia, preterm delivery, and small for gestational age. (PMID:28753968)
• Serum hsa-miR-346 is a potentially useful biomarker of MAC pulmonary disease activity. (PMID:28827075)
• This misrepresentation of the effects of miR-346 in breast cancer could prove harmful by sidetracking future research. Further, clinical trials may be incorrectly directed towards lowering miR-346 without a complete and fair assessment of the internal contradictions in the data (PMID:28888578)
• During endoplasmic reticulum stress miR-346 activated autophagy by interrupting the association between BCL2 and BECN1 in a GSK3B-dependent manner. (PMID:29107113)
• High miR346 expression is associated with Hepatocellular carcinoma. (PMID:29295726)
• Authors conclude that circFBLIM1 may function as a competing endogenous RNA (ceRNA) to regulate FBLIM1 expression through sponging miR-346 to exert regulatory functions in HCC. (PMID:30053867)
• we proved that DGCR5 can rescue the inhibited levels of KLF14 repressed by miR-346 mimics in MHCC-97H and Hep3B cells. Taken together, it was indicated in our study that DGCR5 can restrain the progression of HCC through sponging miR-346 and modulating KLF14 in vitro. (PMID:30216442)
• miR-346 plays a role in upregulation of APP in the CNS and participates in maintaining APP regulation of Fe, which is disrupted in late stages of AD. (PMID:30470799)
• High miR346 expression is associated with cell proliferation, migration, and invasion in renal carcinoma. (PMID:31298469)
• the hsa-miR-346 level was significantly higher in patients with sepsis than in the control group. Hsa-miR-346 inhibited the expression of SMAD3 by targeted its 3’UTR. (PMID:31494280)
• miR-346-5p promoted colorectal cancer cell growth in vitro and in vivo by targeting FBXL2 and activating the beta-catenin signaling. MiR-346-5p can be a promising target in colorectal cancer therapy. (PMID:31953162)
• Oncomir MicroRNA-346 Is Upregulated in Colons of Patients With Primary Sclerosing Cholangitis. (PMID:31972611)
• The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression. (PMID:32131485)
• CircTOP2A acts as a ceRNA for miR346 and contributes to glioma progression via the modulation of sushi domaincontaining 2. (PMID:33537815)
• Potential biomarker enhancing the activity of tuberculosis, hsa-miR-346. (PMID:34144376)
• Hsa_circ_0069244 acts as the sponge of miR-346 to inhibit non-small cell lung cancer progression by regulating XPC expression. (PMID:34228324)
• Tumor suppressor LHX6 upregulation contributes to the inhibitory effect of miR-346 knockdown on colorectal cancer cell growth. (PMID:34773443)
• CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1. (PMID:35032791)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir346	ENSMUSG00000065481
rattus_norvegicus	Mir346	ENSRNOG00000052819

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.