MIR34BHG

Summary

MIR34BHG (MIR34B and MIR34C host gene, HGNC:55987) is a long non-coding RNA gene on chromosome 11q23.1.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing.

Source: NCBI Gene 728196 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55987
Approved symbol	MIR34BHG
Name	MIR34B and MIR34C host gene
Location	11q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	SPARCLE
Ensembl gene	ENSG00000286028
Ensembl biotype	lncRNA
Entrez	728196
RNAcentral	URS00008BFFB5 — lncRNA, 1142 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000651138, ENST00000726427

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000651138 — 2 exons

Exon	Start	End
ENSE00004050967	111510595	111510872
ENSE00004050969	111513018	111513892

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 83.42.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	83.42	gold quality
right uterine tube	UBERON:0001302	82.09	gold quality
fallopian tube	UBERON:0003889	65.26	gold quality
corpus callosum	UBERON:0002336	64.44	gold quality
endometrium	UBERON:0001295	61.05	gold quality
ventricular zone	UBERON:0003053	60.88	gold quality
calcaneal tendon	UBERON:0003701	58.38	gold quality
right lung	UBERON:0002167	56.82	gold quality
lung	UBERON:0002048	55.48	gold quality
stomach	UBERON:0000945	55.10	gold quality
nucleus accumbens	UBERON:0001882	54.95	gold quality
endocervix	UBERON:0000458	53.67	gold quality
caudate nucleus	UBERON:0001873	53.65	gold quality
Brodmann (1909) area 9	UBERON:0013540	53.21	gold quality
skeletal muscle tissue	UBERON:0001134	52.81	silver quality
right testis	UBERON:0004534	52.52	gold quality
ovary	UBERON:0000992	52.14	gold quality
left uterine tube	UBERON:0001303	52.06	gold quality
upper lobe of left lung	UBERON:0008952	52.00	gold quality
multicellular organism	UBERON:0000468	51.69	gold quality
muscle of leg	UBERON:0001383	50.95	gold quality
myometrium	UBERON:0001296	50.87	gold quality
Ammon’s horn	UBERON:0001954	50.68	gold quality
hypothalamus	UBERON:0001898	50.61	gold quality
brain	UBERON:0000955	50.55	gold quality
monocyte	CL:0000576	50.47	silver quality
testis	UBERON:0000473	50.24	gold quality
prefrontal cortex	UBERON:0000451	50.11	gold quality
left testis	UBERON:0004533	50.05	gold quality
gastrocnemius	UBERON:0001388	48.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Results identified a novel lncRNA LOC728196 highly expressed in glioma tissues. LOC728196 high expression predicts low survival rate in patients. Its knockdown repressed cellular growth, migration and invasion in vitro. Further results demonstrated that LOC728196 acts as the sponge for miR-513c to upregulate TCF7 expression. This study suggests a role of LOC728196 in glioma progression (PMID:30179681)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.