MIR3605

Summary

MIR3605 (microRNA 3605, HGNC:38922) is a microRNA gene on chromosome 1p35.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500853 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38922
Approved symbol	MIR3605
Name	microRNA 3605
Location	1p35.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3605
Ensembl gene	ENSG00000284154
Ensembl biotype	miRNA
Entrez	100500853
RNAcentral	URS000075BFBA — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583214

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583214 — 1 exons

Exon	Start	End
ENSE00002731174	33332393	33332492

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 93.82.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	93.82	gold quality
blood	UBERON:0000178	92.47	gold quality
sural nerve	UBERON:0015488	91.97	gold quality
popliteal artery	UBERON:0002250	86.69	gold quality
tibial artery	UBERON:0007610	86.69	gold quality
mucosa of stomach	UBERON:0001199	86.19	gold quality
left coronary artery	UBERON:0001626	85.70	gold quality
metanephros cortex	UBERON:0010533	85.48	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.36	gold quality
ascending aorta	UBERON:0001496	84.32	gold quality
tibial nerve	UBERON:0001323	84.31	gold quality
thoracic aorta	UBERON:0001515	83.91	gold quality
upper lobe of left lung	UBERON:0008952	83.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	82.86	gold quality
right adrenal gland	UBERON:0001233	82.72	gold quality
lung	UBERON:0002048	82.59	gold quality
urinary bladder	UBERON:0001255	82.47	gold quality
left adrenal gland cortex	UBERON:0035825	82.47	gold quality
right uterine tube	UBERON:0001302	82.31	gold quality
left adrenal gland	UBERON:0001234	82.07	gold quality
spleen	UBERON:0002106	81.95	gold quality
myometrium	UBERON:0001296	81.94	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.77	gold quality
body of stomach	UBERON:0001161	81.67	gold quality
adrenal gland	UBERON:0002369	81.67	gold quality
minor salivary gland	UBERON:0001830	81.64	gold quality
lower esophagus	UBERON:0013473	81.63	gold quality
right atrium auricular region	UBERON:0006631	81.59	gold quality
stomach	UBERON:0000945	81.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.