MIR3606

Summary

MIR3606 (microRNA 3606, HGNC:38881) is a microRNA gene on chromosome 2q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500837 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38881
Approved symbol	MIR3606
Name	microRNA 3606
Location	2q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3606
Ensembl gene	ENSG00000284180
Ensembl biotype	miRNA
Entrez	100500837
RNAcentral	URS000075D9F9 — ncRNA, 63 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637672

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637672 — 1 exons

Exon	Start	End
ENSE00003796482	188995630	188995692

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 94.26.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.26	gold quality
calcaneal tendon	UBERON:0003701	78.95	gold quality
adrenal tissue	UBERON:0018303	77.41	gold quality
gastrocnemius	UBERON:0001388	77.08	gold quality
stomach	UBERON:0000945	76.01	gold quality
placenta	UBERON:0001987	75.58	gold quality
blood	UBERON:0000178	74.13	gold quality
kidney	UBERON:0002113	73.45	gold quality
lung	UBERON:0002048	71.40	gold quality
heart left ventricle	UBERON:0002084	70.88	gold quality
islet of Langerhans	UBERON:0000006	70.45	gold quality
endometrium	UBERON:0001295	70.06	gold quality
heart	UBERON:0000948	69.99	gold quality
right atrium auricular region	UBERON:0006631	69.79	gold quality
body of pancreas	UBERON:0001150	69.67	gold quality
ascending aorta	UBERON:0001496	69.63	gold quality
thoracic aorta	UBERON:0001515	69.56	gold quality
intestine	UBERON:0000160	69.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.49	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.33	gold quality
tibial artery	UBERON:0007610	69.23	gold quality
endocervix	UBERON:0000458	68.55	gold quality
colon	UBERON:0001155	68.38	gold quality
body of stomach	UBERON:0001161	67.86	gold quality
body of uterus	UBERON:0009853	67.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.18	gold quality
minor salivary gland	UBERON:0001830	67.13	gold quality
lower esophagus	UBERON:0013473	67.07	gold quality
esophagus	UBERON:0001043	67.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-3606-3p acts, at least partly, through the attenuation of TGF-beta signaling via TGFBR2 repression. (PMID:30145936)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.