MIR3609

Summary

MIR3609 (microRNA 3609, HGNC:38956) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500819 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38956
Approved symbol	MIR3609
Name	microRNA 3609
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3609
Ensembl gene	ENSG00000266019
Ensembl biotype	miRNA
Entrez	100500819
RNAcentral	URS000075D1DB — ncRNA, 80 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582661

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582661 — 1 exons

Exon	Start	End
ENSE00002689183	98881650	98881729

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 99.91.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	99.91	gold quality
sural nerve	UBERON:0015488	99.17	gold quality
kidney	UBERON:0002113	83.78	gold quality
blood	UBERON:0000178	80.06	gold quality
adult mammalian kidney	UBERON:0000082	79.26	gold quality
corpus callosum	UBERON:0002336	77.72	gold quality
placenta	UBERON:0001987	77.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.26	gold quality
monocyte	CL:0000576	74.14	gold quality
liver	UBERON:0002107	73.95	gold quality
endometrium	UBERON:0001295	72.69	gold quality
islet of Langerhans	UBERON:0000006	72.40	gold quality
stomach	UBERON:0000945	71.43	gold quality
heart	UBERON:0000948	70.68	gold quality
lung	UBERON:0002048	70.07	gold quality
gastrocnemius	UBERON:0001388	70.06	gold quality
right atrium auricular region	UBERON:0006631	69.56	gold quality
tibial nerve	UBERON:0001323	68.73	gold quality
left adrenal gland	UBERON:0001234	66.53	gold quality
heart left ventricle	UBERON:0002084	66.40	gold quality
body of stomach	UBERON:0001161	66.38	gold quality
tibial artery	UBERON:0007610	65.97	gold quality
body of pancreas	UBERON:0001150	65.63	gold quality
esophagus mucosa	UBERON:0002469	65.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.61	gold quality
left ovary	UBERON:0002119	65.51	gold quality
esophagus	UBERON:0001043	65.48	gold quality
Ammon’s horn	UBERON:0001954	65.07	gold quality
intestine	UBERON:0000160	64.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• low miR-3609 expression and high PD-L1 expression were correlated with poor prognosis in breast cancer patients. Therefore, restoration of miR-3609 expression may sensitize breast cancer to adriamycin by blocking PD-L1 expression. (PMID:30904483)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.