MIR3610

Summary

MIR3610 (microRNA 3610, HGNC:38942) is a microRNA gene on chromosome 8q24.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500914 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38942
Approved symbol	MIR3610
Name	microRNA 3610
Location	8q24.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3610
Ensembl gene	ENSG00000283956
Ensembl biotype	miRNA
Entrez	100500914
RNAcentral	URS000075EC53 — ncRNA, 73 nt, 21 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582903

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582903 — 1 exons

Exon	Start	End
ENSE00002695110	116874728	116874800

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 85.39.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 84.2621 / max 1535.8367, expressed in 1822 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94550	84.2621	1822

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	85.39	gold quality
skeletal muscle tissue	UBERON:0001134	85.06	gold quality
lymph node	UBERON:0000029	76.88	gold quality
heart left ventricle	UBERON:0002084	76.38	gold quality
body of pancreas	UBERON:0001150	75.70	gold quality
prefrontal cortex	UBERON:0000451	74.57	gold quality
muscle of leg	UBERON:0001383	72.67	gold quality
blood	UBERON:0000178	71.92	gold quality
gastrocnemius	UBERON:0001388	71.70	gold quality
islet of Langerhans	UBERON:0000006	71.60	gold quality
right atrium auricular region	UBERON:0006631	68.78	gold quality
stomach	UBERON:0000945	68.53	gold quality
tibial artery	UBERON:0007610	68.50	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.20	gold quality
spleen	UBERON:0002106	66.99	gold quality
right lobe of liver	UBERON:0001114	66.44	gold quality
colon	UBERON:0001155	66.41	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.39	gold quality
omental fat pad	UBERON:0010414	65.47	gold quality
transverse colon	UBERON:0001157	65.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.31	gold quality
anterior cingulate cortex	UBERON:0009835	64.00	gold quality
cerebral cortex	UBERON:0000956	63.19	gold quality
body of stomach	UBERON:0001161	63.00	gold quality
putamen	UBERON:0001874	62.94	gold quality
ascending aorta	UBERON:0001496	62.93	gold quality
skin of leg	UBERON:0001511	62.42	gold quality
skin of abdomen	UBERON:0001416	62.24	gold quality
ovary	UBERON:0000992	61.90	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Our results indicated that altered expression of miR-126-3p and miR-3610 may play an important role in the development of traumatic brain injury-induced hypopituitarism. (PMID:27027233)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.