MIR3611

Summary

MIR3611 (microRNA 3611, HGNC:38914) is a microRNA gene on chromosome 10p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500890 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38914
Approved symbol	MIR3611
Name	microRNA 3611
Location	10p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3611
Ensembl gene	ENSG00000266228
Ensembl biotype	miRNA
Entrez	100500890
RNAcentral	URS000075C882 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584484

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584484 — 1 exons

Exon	Start	End
ENSE00002717949	35079598	35079680

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 81.63.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	81.63	gold quality
blood	UBERON:0000178	79.45	gold quality
adrenal tissue	UBERON:0018303	76.71	gold quality
calcaneal tendon	UBERON:0003701	75.78	gold quality
heart	UBERON:0000948	74.44	gold quality
endometrium	UBERON:0001295	74.18	gold quality
stomach	UBERON:0000945	73.99	gold quality
gastrocnemius	UBERON:0001388	73.38	gold quality
adult mammalian kidney	UBERON:0000082	73.33	gold quality
monocyte	CL:0000576	71.50	gold quality
intestine	UBERON:0000160	71.30	gold quality
heart left ventricle	UBERON:0002084	70.71	gold quality
right ovary	UBERON:0002118	69.92	gold quality
liver	UBERON:0002107	69.75	gold quality
lung	UBERON:0002048	69.38	gold quality
left adrenal gland	UBERON:0001234	69.21	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.95	gold quality
anterior cingulate cortex	UBERON:0009835	68.74	gold quality
thoracic aorta	UBERON:0001515	68.36	gold quality
substantia nigra	UBERON:0002038	67.66	gold quality
colon	UBERON:0001155	67.01	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.83	gold quality
body of stomach	UBERON:0001161	66.59	gold quality
Ammon’s horn	UBERON:0001954	66.48	gold quality
body of pancreas	UBERON:0001150	66.13	gold quality
corpus callosum	UBERON:0002336	66.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.35	gold quality
skin of abdomen	UBERON:0001416	65.28	gold quality
right lobe of thyroid gland	UBERON:0001119	65.24	gold quality
skin of leg	UBERON:0001511	65.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.