MIR3612

Summary

MIR3612 (microRNA 3612, HGNC:38951) is a microRNA gene on chromosome 12q24.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500817 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38951
Approved symbol	MIR3612
Name	microRNA 3612
Location	12q24.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3612
Ensembl gene	ENSG00000265635
Ensembl biotype	miRNA
Entrez	100500817
RNAcentral	URS0000759B3B — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579753

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579753 — 1 exons

Exon	Start	End
ENSE00002699201	128294092	128294178

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 90.80.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	90.80	gold quality
kidney	UBERON:0002113	88.19	gold quality
heart	UBERON:0000948	87.26	gold quality
adrenal tissue	UBERON:0018303	84.57	gold quality
lung	UBERON:0002048	84.23	gold quality
intestine	UBERON:0000160	79.87	gold quality
stomach	UBERON:0000945	72.96	gold quality
body of pancreas	UBERON:0001150	71.35	gold quality
monocyte	CL:0000576	70.55	gold quality
corpus callosum	UBERON:0002336	70.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.52	gold quality
body of stomach	UBERON:0001161	68.63	gold quality
endometrium	UBERON:0001295	67.91	gold quality
prefrontal cortex	UBERON:0000451	67.45	gold quality
left ovary	UBERON:0002119	67.19	gold quality
endocervix	UBERON:0000458	67.18	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.12	gold quality
substantia nigra	UBERON:0002038	66.93	gold quality
colon	UBERON:0001155	66.82	gold quality
tibial nerve	UBERON:0001323	66.38	gold quality
omental fat pad	UBERON:0010414	66.14	gold quality
nucleus accumbens	UBERON:0001882	66.03	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.88	gold quality
hypothalamus	UBERON:0001898	64.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.57	gold quality
skin of abdomen	UBERON:0001416	64.55	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.79	gold quality
vagina	UBERON:0000996	63.47	gold quality
thoracic mammary gland	UBERON:0005200	63.18	gold quality
minor salivary gland	UBERON:0001830	63.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• ZFPM2-AS1 facilitates cell growth in esophageal squamous cell carcinoma via up-regulating TRAF4. (PMID:32065218)
• Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis. (PMID:34024023)
• LncRNA MAFG-AS1 deregulated in breast cancer affects autophagy and progression of breast cancer by interacting with miR-3612 and FKBP4 invitro. (PMID:35653827)
• LncRNA ZFPM2-AS1 Enhances Retinoblastoma Development by Targeting the miR-3612/NT5E Signaling Axis. (PMID:35997119)
• MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway. (PMID:36607163)
• Hypoxia-induced factor-1alpha promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia. (PMID:37983895)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.