MIR3613

Summary

MIR3613 (microRNA 3613, HGNC:38964) is a microRNA gene on chromosome 13q14.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500908 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38964
Approved symbol	MIR3613
Name	microRNA 3613
Location	13q14.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3613
Ensembl gene	ENSG00000264864
Ensembl biotype	miRNA
Entrez	100500908
RNAcentral	URS000075BBF3 — miRNA, 87 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579844

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579844 — 1 exons

Exon	Start	End
ENSE00002685139	49996415	49996501

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 91.65.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.65	gold quality
skeletal muscle tissue	UBERON:0001134	85.68	gold quality
duodenum	UBERON:0002114	81.03	gold quality
bone marrow	UBERON:0002371	80.03	gold quality
blood	UBERON:0000178	77.46	gold quality
prefrontal cortex	UBERON:0000451	77.17	gold quality
adrenal tissue	UBERON:0018303	77.00	gold quality
islet of Langerhans	UBERON:0000006	75.95	gold quality
calcaneal tendon	UBERON:0003701	75.91	gold quality
placenta	UBERON:0001987	75.80	gold quality
muscle of leg	UBERON:0001383	74.86	gold quality
monocyte	CL:0000576	74.35	gold quality
adult mammalian kidney	UBERON:0000082	74.18	gold quality
endometrium	UBERON:0001295	73.58	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.20	gold quality
gastrocnemius	UBERON:0001388	73.11	gold quality
left adrenal gland cortex	UBERON:0035825	72.55	gold quality
urinary bladder	UBERON:0001255	71.27	gold quality
right atrium auricular region	UBERON:0006631	70.62	gold quality
heart left ventricle	UBERON:0002084	70.61	gold quality
ascending aorta	UBERON:0001496	70.27	gold quality
body of pancreas	UBERON:0001150	70.26	gold quality
heart	UBERON:0000948	70.20	gold quality
left uterine tube	UBERON:0001303	70.00	gold quality
popliteal artery	UBERON:0002250	70.00	gold quality
tibial artery	UBERON:0007610	69.97	gold quality
right adrenal gland cortex	UBERON:0035827	69.93	gold quality
thoracic aorta	UBERON:0001515	69.92	gold quality
right lobe of liver	UBERON:0001114	69.78	gold quality
right adrenal gland	UBERON:0001233	69.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• expression of miR-3613-3p might be regulated by MCPIP1 by cleavage of its precursor form. (PMID:26308737)
• We identified a specific whole blood miRNA (miR-3613-3p) that may serve to distinguish between dedifferentiated liposarcoma patients and healthy controls, thus potentially serving as a specific biomarker for dedifferentiated liposarcoma. (PMID:29689704)
• Study suggests a potential underlying molecular mechanism of apoptosis inhibition via APAF1 downregulation in human neuroblastoma BE(2)C cells with miRNA36133p overexpression. (PMID:30066861)
• these results indicated that miR36133p may have complicated roles in endothelial cells (ECs) under heat stress. miR36133p may serve an important role in the apoptosis of heattreated ECs, and this effect may be partly achieved by targeting MAP3K2. (PMID:31257536)
• Targeting CDC7 sensitizes resistance melanoma cells to BRAF(V600E)-specific inhibitor by blocking the CDC7/MCM2-7 pathway. (PMID:31578454)
• MiR-3613-3p from carcinoma-associated fibroblasts exosomes promoted breast cancer cell proliferation and metastasis by regulating SOCS2 expression. (PMID:32344463)
• miR-3613-5p enhances the metastasis of pancreatic cancer by targeting CDK6. (PMID:33073681)
• MiR-3613-3p inhibits hypertrophic scar formation by down-regulating arginine and glutamate-rich 1. (PMID:33165823)
• MicroRNA-3613-3p functions as a tumor suppressor and represents a novel therapeutic target in breast cancer. (PMID:33494814)
• miR36133p/MAP3K2/p38/caspase3 pathway regulates the heatstressinduced apoptosis of endothelial cells. (PMID:34278472)
• LncRNA BBOX1-AS1 Contributes to the Progression of Esophageal Carcinoma by Targeting the miR-361-3p/COL5A1 Axis. (PMID:36586008)
• Introduction of miR-3613-3p as a regulator of transforming growth factor-beta (TGF-beta) signaling pathway in colorectal cancer. (PMID:38861185)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.