MIR3614

Summary

MIR3614 (microRNA 3614, HGNC:38995) is a microRNA gene on chromosome 17q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500827 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38995
Approved symbol	MIR3614
Name	microRNA 3614
Location	17q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3614
Ensembl gene	ENSG00000284542
Ensembl biotype	miRNA
Entrez	100500827
RNAcentral	URS000075E293 — ncRNA, 86 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581261

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581261 — 1 exons

Exon	Start	End
ENSE00002705743	56891270	56891355

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 85.24.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.24	gold quality
endometrium	UBERON:0001295	82.85	gold quality
muscle of leg	UBERON:0001383	72.96	gold quality
gastrocnemius	UBERON:0001388	72.51	gold quality
right lobe of thyroid gland	UBERON:0001119	66.41	gold quality
right frontal lobe	UBERON:0002810	64.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• The miRNAs that were found upregulated in DENV-infected cells did not control the production of infectious virus particles. On the other hand, miR-3614-5p, which was upregulated in DENV-negative macrophages, reduced DENV infectivity and regulated ADAR1 expression, a protein that facilitates viral replication. (PMID:29045406)
• Evidence has been presented for a potential role of miR-1908-5p and miR-3614-5p in Crohn’s disease and rheumatoid arthritis disease risk. (PMID:30143393)
• The overexpression of miR-3614-3p dramatically inhibited breast cancer cell growth through the downregulation of TRIM25. (PMID:30797711)
• PGAM1, regulated by miR-3614-5p, functions as an oncogene by activating transforming growth factor-beta (TGF-beta) signaling in the progression of non-small cell lung carcinoma. (PMID:32855383)
• MicroRNA-3614 regulates inflammatory response via targeting TRAF6-mediated MAPKs and NF-kappaB signaling in the epicardial adipose tissue with coronary artery disease. (PMID:32950591)
• LncRNA RGMB-AS1 up-regulates ANKRD1 Through Competitively Sponging miR-3614-5p to Promote OSA Cell Proliferation and Invasion. (PMID:34583851)
• Study on the mechanism of LOXL1-AS1/miR-3614-5p/YY1 signal axis in the malignant phenotype regulation of hepatocellular carcinoma. (PMID:34863279)
• Targeting of Mcl-1 Expression by MiRNA-3614-5p Promotes Cell Apoptosis of Human Prostate Cancer Cells. (PMID:35457012)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.