MIR3615

Summary

MIR3615 (microRNA 3615, HGNC:38905) is a microRNA gene on chromosome 17q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500847 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38905
Approved symbol	MIR3615
Name	microRNA 3615
Location	17q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3615
Ensembl gene	ENSG00000284186
Ensembl biotype	miRNA
Entrez	100500847
RNAcentral	URS000075A6B9 — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581999

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581999 — 1 exons

Exon	Start	End
ENSE00002719279	74748613	74748699

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 77.32.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	77.32	gold quality
stomach	UBERON:0000945	75.85	gold quality
heart	UBERON:0000948	70.91	gold quality
heart left ventricle	UBERON:0002084	70.23	gold quality
adult mammalian kidney	UBERON:0000082	68.86	gold quality
muscle of leg	UBERON:0001383	68.31	gold quality
blood	UBERON:0000178	68.18	gold quality
gastrocnemius	UBERON:0001388	67.60	gold quality
adrenal tissue	UBERON:0018303	67.52	gold quality
putamen	UBERON:0001874	67.42	gold quality
left adrenal gland	UBERON:0001234	67.39	gold quality
esophagus mucosa	UBERON:0002469	66.71	gold quality
minor salivary gland	UBERON:0001830	66.15	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.98	gold quality
anterior cingulate cortex	UBERON:0009835	65.68	gold quality
adipose tissue	UBERON:0001013	64.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.52	gold quality
upper lobe of left lung	UBERON:0008952	64.47	gold quality
hypothalamus	UBERON:0001898	64.18	gold quality
left ovary	UBERON:0002119	63.90	gold quality
caudate nucleus	UBERON:0001873	63.37	gold quality
transverse colon	UBERON:0001157	63.32	gold quality
placenta	UBERON:0001987	63.24	gold quality
omental fat pad	UBERON:0010414	63.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.74	gold quality
skin of leg	UBERON:0001511	62.37	gold quality
tibial artery	UBERON:0007610	62.27	gold quality
vagina	UBERON:0000996	62.12	gold quality
skin of abdomen	UBERON:0001416	60.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Expression and clinical significance of miR-3615 in hepatocellular carcinoma. (PMID:33435769)
• An evaluation of the role of miR-361-5p in senescence and systemic ageing. (PMID:36804517)
• NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis. (PMID:36912070)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.