MIR3616

Summary

MIR3616 (microRNA 3616, HGNC:38943) is a microRNA gene on chromosome 20q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500814 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38943
Approved symbol	MIR3616
Name	microRNA 3616
Location	20q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3616
Ensembl gene	ENSG00000264901
Ensembl biotype	miRNA
Entrez	100500814
RNAcentral	URS000075D53C — miRNA, 92 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584070

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584070 — 1 exons

Exon	Start	End
ENSE00002708413	47166967	47167058

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 75.23.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	75.23	gold quality
endometrium	UBERON:0001295	74.61	gold quality
left adrenal gland cortex	UBERON:0035825	73.43	gold quality
muscle of leg	UBERON:0001383	73.38	gold quality
right uterine tube	UBERON:0001302	73.17	gold quality
adrenal tissue	UBERON:0018303	73.05	gold quality
adult mammalian kidney	UBERON:0000082	72.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.77	gold quality
hypothalamus	UBERON:0001898	72.34	gold quality
monocyte	CL:0000576	72.29	gold quality
gastrocnemius	UBERON:0001388	71.56	gold quality
left uterine tube	UBERON:0001303	71.30	gold quality
body of stomach	UBERON:0001161	70.83	gold quality
heart left ventricle	UBERON:0002084	70.80	gold quality
stomach	UBERON:0000945	70.35	gold quality
body of pancreas	UBERON:0001150	70.34	gold quality
minor salivary gland	UBERON:0001830	70.18	gold quality
right atrium auricular region	UBERON:0006631	69.77	gold quality
tibial artery	UBERON:0007610	69.28	gold quality
ectocervix	UBERON:0012249	69.01	gold quality
lymph node	UBERON:0000029	68.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.40	gold quality
right ovary	UBERON:0002118	68.31	gold quality
lower esophagus	UBERON:0013473	68.27	gold quality
transverse colon	UBERON:0001157	68.20	gold quality
endocervix	UBERON:0000458	67.88	gold quality
esophagus mucosa	UBERON:0002469	67.84	gold quality
fallopian tube	UBERON:0003889	67.84	gold quality
colon	UBERON:0001155	67.66	gold quality
amygdala	UBERON:0001876	67.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.51

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.