MIR3617

Summary

MIR3617 (microRNA 3617, HGNC:38977) is a microRNA gene on chromosome 20q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500897 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38977
Approved symbol	MIR3617
Name	microRNA 3617
Location	20q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3617
Ensembl gene	ENSG00000266071
Ensembl biotype	miRNA
Entrez	100500897
RNAcentral	URS000075CD65 — miRNA, 79 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577518

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577518 — 1 exons

Exon	Start	End
ENSE00002714170	45705102	45705180

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 85.18.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	85.18	gold quality
blood	UBERON:0000178	75.28	gold quality
monocyte	CL:0000576	75.15	gold quality
lymph node	UBERON:0000029	71.86	gold quality
fundus of stomach	UBERON:0001160	71.34	gold quality
right atrium auricular region	UBERON:0006631	70.14	gold quality
urinary bladder	UBERON:0001255	69.57	gold quality
endometrium	UBERON:0001295	68.97	gold quality
tibial artery	UBERON:0007610	68.13	gold quality
caudate nucleus	UBERON:0001873	68.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.81	gold quality
rectum	UBERON:0001052	67.04	gold quality
left coronary artery	UBERON:0001626	66.74	gold quality
esophagus mucosa	UBERON:0002469	66.23	gold quality
skin of leg	UBERON:0001511	66.20	gold quality
skin of abdomen	UBERON:0001416	65.91	gold quality
thoracic aorta	UBERON:0001515	65.76	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.74	gold quality
adult mammalian kidney	UBERON:0000082	65.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.39	gold quality
transverse colon	UBERON:0001157	65.35	gold quality
ascending aorta	UBERON:0001496	65.19	gold quality
body of stomach	UBERON:0001161	65.18	gold quality
colon	UBERON:0001155	65.07	gold quality
intestine	UBERON:0000160	65.05	gold quality
left ovary	UBERON:0002119	64.61	gold quality
vagina	UBERON:0000996	64.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.07	gold quality
stomach	UBERON:0000945	63.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.58

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.