MIR3618

Summary

MIR3618 (microRNA 3618, HGNC:38937) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500860 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38937
Approved symbol	MIR3618
Name	microRNA 3618
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3618
Ensembl gene	ENSG00000284140
Ensembl biotype	miRNA
Entrez	100500860
RNAcentral	URS000075BA45 — miRNA, 88 nt, 101 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580330

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580330 — 1 exons

Exon	Start	End
ENSE00002717242	20085746	20085833

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 78.37.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.37	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.58	gold quality
fundus of stomach	UBERON:0001160	59.40	gold quality
nucleus accumbens	UBERON:0001882	56.60	gold quality
substantia nigra	UBERON:0002038	55.95	gold quality
colon	UBERON:0001155	52.04	gold quality
skin of leg	UBERON:0001511	49.48	gold quality
right frontal lobe	UBERON:0002810	45.86	gold quality
putamen	UBERON:0001874	44.76	gold quality
omental fat pad	UBERON:0010414	39.28	silver quality
upper lobe of left lung	UBERON:0008952	37.81	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir3618	ENSMUSG00000093246
rattus_norvegicus	Gm24572	ENSRNOG00000049439

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.