MIR3619

Summary

MIR3619 (microRNA 3619, HGNC:38998) is a microRNA gene on chromosome 22q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500828 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38998
Approved symbol	MIR3619
Name	microRNA 3619
Location	22q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3619
Ensembl gene	ENSG00000266533
Ensembl biotype	miRNA
Entrez	100500828
RNAcentral	URS000075C055 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579667

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579667 — 1 exons

Exon	Start	End
ENSE00002729839	46091044	46091126

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 91.04.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.04	gold quality
adrenal tissue	UBERON:0018303	85.90	gold quality
blood	UBERON:0000178	83.43	gold quality
corpus callosum	UBERON:0002336	78.91	gold quality
adult mammalian kidney	UBERON:0000082	78.45	gold quality
placenta	UBERON:0001987	75.39	gold quality
liver	UBERON:0002107	75.14	gold quality
muscle of leg	UBERON:0001383	75.10	gold quality
monocyte	CL:0000576	74.90	gold quality
endometrium	UBERON:0001295	74.32	gold quality
gastrocnemius	UBERON:0001388	74.06	gold quality
stomach	UBERON:0000945	73.81	gold quality
right adrenal gland cortex	UBERON:0035827	72.35	gold quality
heart left ventricle	UBERON:0002084	71.03	gold quality
heart	UBERON:0000948	70.97	gold quality
body of stomach	UBERON:0001161	69.67	gold quality
right adrenal gland	UBERON:0001233	69.67	gold quality
body of pancreas	UBERON:0001150	68.95	gold quality
left coronary artery	UBERON:0001626	68.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.66	gold quality
right atrium auricular region	UBERON:0006631	68.42	gold quality
left adrenal gland cortex	UBERON:0035825	68.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.25	gold quality
colon	UBERON:0001155	67.99	gold quality
tibial artery	UBERON:0007610	67.74	gold quality
popliteal artery	UBERON:0002250	67.68	gold quality
skin of abdomen	UBERON:0001416	67.64	gold quality
zone of skin	UBERON:0000014	67.52	gold quality
left adrenal gland	UBERON:0001234	67.43	gold quality
right coronary artery	UBERON:0001625	67.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• miR-3619-5p overexpression resulted in suppression of NSCLC cell growth and invasion, while miR-3619-5p depletion increased NSCLC growth and invasion. (PMID:26512718)
• Low aggressive MCF-7 breast cancer cells have low endogenous PLD enzymatic activity and cell invasion, concomitant with high expression of miR-203, -887, and -3619 and miR-182 and miR-182. (PMID:26567912)
• Antitumor function of miR-3619-5p was mainly achieved by stimulating CDKN1A expression in prostate cancer cells. (PMID:27878260)
• circZFR may exert carcinogenic role in HCC through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/beta-catenin pathway (PMID:30468709)
• high LINC00202 levels are correlated with poor prognosis in RB, and it promotes RB progression by sponging miR-3619-5p and therefore up-regulating RIN1 expression (PMID:30905893)
• miR-3619-5p inhibited cell proliferation and cisplatin resistance of cutaneous squamous cell carcinoma (CSCC) by regulating KPNA4 expression, suggesting that miR-3619-5p/KPNA4 pathway may represent a potential promising strategy for the treatment of patients with CSCC. (PMID:30967266)
• LINC00882 promotes platelet-derived growth factor-induced cell proliferation of airway smooth muscle cells by enhancing Wnt/beta-catenin signaling via sponging miR-3619-5p, suggesting a potential role for LINC00882 in airway remodeling in pediatric asthma. (PMID:31014672)
• STAT4-mediated down-regulation of miR-3619-5p facilitates stomach adenocarcinoma by modulating TBC1D10B. (PMID:32397798)
• findings revealed that miR-3619-5p inhibits cancer cell proliferation by targeting PSMD10, and miR-3619-5p as a potential therapeutic target for the treatment of liver cancer (PMID:32437796)
• Downregulation of LINC00958 inhibits proliferation, invasion and migration, and promotes apoptosis of colorectal cancer cells by targeting miR36195p. (PMID:32945474)
• Knockdown of LINC00665 inhibits proliferation and invasion of breast cancer via competitive binding of miR-3619-5p and inhibition of catenin beta 1. (PMID:32983239)
• LINC00665 facilitates the progression of osteosarcoma via sponging miR-3619-5p. (PMID:33090388)
• Exosomal lncRNA HEIH promotes cisplatin resistance in tongue squamous cell carcinoma via targeting miR-3619-5p/HDGF axis. (PMID:33130420)
• lncRNA LINC01535 upregulates BMP2 expression levels to promote osteogenic differentiation via sponging miR36195p. (PMID:33174047)
• Knockdown of long noncoding RNA HCP5 suppresses the malignant behavior of retinoblastoma by sponging miR36195p to target HDAC9. (PMID:33693951)
• Long noncoding HOXA11-AS knockdown suppresses the progression of non-small cell lung cancer by regulating miR-3619-5p/SALL4 axis. (PMID:34050851)
• LINC00882 Plays a Tumor-promoter Role in Colorectal Cancer by Targeting miR-3619-5p to Up-regulate CTNNB1. (PMID:34399990)
• M2 macrophage facilitated angiogenesis in cutaneous squamous cell carcinoma via circ_TNFRSF21/miR-3619-5p/ROCK axis. (PMID:35593591)
• LncRNA PVT1 facilitates the growth and metastasis of colorectal cancer by sponging with miR-3619-5p to regulate TRIM29 expression. (PMID:38837682)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.