MIR3620

Summary

MIR3620 (microRNA 3620, HGNC:38917) is a microRNA gene on chromosome 1q42.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500810 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38917
Approved symbol	MIR3620
Name	microRNA 3620
Location	1q42.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3620
Ensembl gene	ENSG00000284163
Ensembl biotype	miRNA
Entrez	100500810
RNAcentral	URS000075F100 — ncRNA, 79 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584469

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584469 — 1 exons

Exon	Start	End
ENSE00002732084	228097263	228097341

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 68.30.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	68.30	gold quality
left lobe of thyroid gland	UBERON:0001120	67.91	gold quality
body of pancreas	UBERON:0001150	67.47	gold quality
right atrium auricular region	UBERON:0006631	64.72	gold quality
endometrium	UBERON:0001295	63.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.46	gold quality
gastrocnemius	UBERON:0001388	62.66	gold quality
caudate nucleus	UBERON:0001873	62.66	gold quality
tibial nerve	UBERON:0001323	62.62	gold quality
Ammon’s horn	UBERON:0001954	62.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	58.58	gold quality
minor salivary gland	UBERON:0001830	58.45	gold quality
transverse colon	UBERON:0001157	57.10	gold quality
substantia nigra	UBERON:0002038	55.81	gold quality
body of stomach	UBERON:0001161	55.76	gold quality
heart left ventricle	UBERON:0002084	55.60	gold quality
skin of leg	UBERON:0001511	54.76	gold quality
nucleus accumbens	UBERON:0001882	54.16	gold quality
muscle layer of sigmoid colon	UBERON:0035805	51.98	gold quality
esophagus mucosa	UBERON:0002469	50.10	gold quality
ascending aorta	UBERON:0001496	49.20	gold quality
subcutaneous adipose tissue	UBERON:0002190	48.38	gold quality
skin of abdomen	UBERON:0001416	47.97	gold quality
tibial artery	UBERON:0007610	45.73	silver quality
prostate gland	UBERON:0002367	38.48	silver quality
left testis	UBERON:0004533	24.66	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.