MIR3621

Summary

MIR3621 (microRNA 3621, HGNC:38930) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500811 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38930
Approved symbol	MIR3621
Name	microRNA 3621
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3621
Ensembl gene	ENSG00000263697
Ensembl biotype	miRNA
Entrez	100500811
RNAcentral	URS000075D844 — ncRNA, 85 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580529

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580529 — 1 exons

Exon	Start	End
ENSE00002709199	137169186	137169270

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 82.29.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.29	gold quality
nucleus accumbens	UBERON:0001882	71.26	gold quality
colon	UBERON:0001155	70.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.33	gold quality
right frontal lobe	UBERON:0002810	68.83	gold quality
transverse colon	UBERON:0001157	68.59	gold quality
body of stomach	UBERON:0001161	67.20	gold quality
caudate nucleus	UBERON:0001873	66.57	gold quality
vagina	UBERON:0000996	66.31	gold quality
minor salivary gland	UBERON:0001830	65.94	gold quality
esophagus mucosa	UBERON:0002469	65.64	gold quality
skin of abdomen	UBERON:0001416	64.62	gold quality
hypothalamus	UBERON:0001898	63.47	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.11	gold quality
anterior cingulate cortex	UBERON:0009835	63.00	gold quality
skin of leg	UBERON:0001511	62.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.70	gold quality
cerebellar hemisphere	UBERON:0002245	61.55	gold quality
thoracic mammary gland	UBERON:0005200	61.07	gold quality
prostate gland	UBERON:0002367	60.68	gold quality
substantia nigra	UBERON:0002038	60.60	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	57.88	gold quality
left testis	UBERON:0004533	45.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.09

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.