MIR3622A

Summary

MIR3622A (microRNA 3622a, HGNC:38934) is a microRNA gene on chromosome 8p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500858 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38934
Approved symbol	MIR3622A
Name	microRNA 3622a
Location	8p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3622a
Ensembl gene	ENSG00000284351
Ensembl biotype	miRNA
Entrez	100500858
RNAcentral	URS000075D590 — miRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636365

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636365 — 1 exons

Exon	Start	End
ENSE00003793122	27701677	27701759

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 68.90.

Top tissues by expression

2 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nucleus accumbens	UBERON:0001882	68.90	gold quality
Ammon’s horn	UBERON:0001954	37.34	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• results indicate that miR-3622a promotes the proliferation and invasion of bladder cancer cells by downregulating LASS2. (PMID:30898713)
• MiR-3622a-3p acts as a tumor suppressor in colorectal cancer by reducing stemness features and EMT through targeting spalt-like transcription factor 4. (PMID:32719361)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.