MIR3622B

Summary

MIR3622B (microRNA 3622b, HGNC:38961) is a microRNA gene on chromosome 8p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500871 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38961
Approved symbol	MIR3622B
Name	microRNA 3622b
Location	8p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3622b
Ensembl gene	ENSG00000265075
Ensembl biotype	miRNA
Entrez	100500871
RNAcentral	URS000075EC50 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584551

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584551 — 1 exons

Exon	Start	End
ENSE00002687947	27701673	27701767

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 74.89.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	74.89	gold quality
ascending aorta	UBERON:0001496	72.11	gold quality
vagina	UBERON:0000996	67.39	gold quality
tibial artery	UBERON:0007610	65.09	gold quality
body of stomach	UBERON:0001161	65.06	gold quality
left coronary artery	UBERON:0001626	64.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.82	gold quality
right lobe of liver	UBERON:0001114	62.55	gold quality
esophagus mucosa	UBERON:0002469	62.16	gold quality
cerebellar hemisphere	UBERON:0002245	60.74	gold quality
omental fat pad	UBERON:0010414	60.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.37	gold quality
nucleus accumbens	UBERON:0001882	58.98	gold quality
mucosa of stomach	UBERON:0001199	57.19	gold quality
anterior cingulate cortex	UBERON:0009835	56.54	gold quality
tibial nerve	UBERON:0001323	56.20	gold quality
minor salivary gland	UBERON:0001830	55.63	gold quality
skin of leg	UBERON:0001511	55.31	gold quality
caudate nucleus	UBERON:0001873	53.63	gold quality
left lobe of thyroid gland	UBERON:0001120	44.73	silver quality
metanephros cortex	UBERON:0010533	38.87	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.