MIR3646

Summary

MIR3646 (microRNA 3646, HGNC:38935) is a microRNA gene on chromosome 20q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500813 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38935
Approved symbol	MIR3646
Name	microRNA 3646
Location	20q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3646
Ensembl gene	ENSG00000266151
Ensembl biotype	miRNA
Entrez	100500813
RNAcentral	URS000075CAFA — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578301

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578301 — 1 exons

Exon	Start	End
ENSE00002687460	44408120	44408203

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 86.84.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	86.84	gold quality
liver	UBERON:0002107	86.63	gold quality
right lobe of liver	UBERON:0001114	86.18	gold quality
rectum	UBERON:0001052	85.66	gold quality
duodenum	UBERON:0002114	84.82	gold quality
small intestine	UBERON:0002108	82.13	gold quality
small intestine Peyer’s patch	UBERON:0003454	81.64	gold quality
blood	UBERON:0000178	80.96	gold quality
intestine	UBERON:0000160	80.63	gold quality
transverse colon	UBERON:0001157	80.12	gold quality
colon	UBERON:0001155	79.12	gold quality
adult mammalian kidney	UBERON:0000082	77.66	gold quality
kidney	UBERON:0002113	76.62	gold quality
multicellular organism	UBERON:0000468	76.10	gold quality
islet of Langerhans	UBERON:0000006	75.58	gold quality
adrenal tissue	UBERON:0018303	74.61	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.41	gold quality
stomach	UBERON:0000945	73.41	gold quality
body of stomach	UBERON:0001161	71.26	gold quality
metanephros cortex	UBERON:0010533	70.67	gold quality
left adrenal gland	UBERON:0001234	70.61	gold quality
body of pancreas	UBERON:0001150	70.48	gold quality
left adrenal gland cortex	UBERON:0035825	67.59	gold quality
tibial artery	UBERON:0007610	67.39	gold quality
fallopian tube	UBERON:0003889	66.49	gold quality
skin of leg	UBERON:0001511	65.66	gold quality
mucosa of transverse colon	UBERON:0004991	64.48	gold quality
spleen	UBERON:0002106	63.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.53	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Up-regulation of miR-3646 in nipple discharge is associated with malignant breast cancer. (PMID:25976861)
• microRNA-3646 serves as a diagnostic marker and mediates the inflammatory response induced by acute coronary syndrome. (PMID:34519257)
• MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway. (PMID:35196185)
• MiR-3646 accelerates inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis in hypertension model. (PMID:36751048)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.