MIR3648-2

Summary

MIR3648-2 (microRNA 3648-2, HGNC:50843) is a microRNA gene on chromosome 21p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 103504731 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50843
Approved symbol	MIR3648-2
Name	microRNA 3648-2
Location	21p11.2
Locus type	RNA, micro
Status	Approved
Ensembl gene	ENSG00000264462
Ensembl biotype	miRNA
Entrez	103504731
RNAcentral	URS000075A546 — miRNA, 180 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581792

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581792 — 1 exons

Exon	Start	End
ENSE00002687018	8986999	8987178

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 99.91.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	99.91	gold quality
sural nerve	UBERON:0015488	99.88	gold quality
colonic epithelium	UBERON:0000397	99.79	gold quality
mucosa of transverse colon	UBERON:0004991	94.67	gold quality
tonsil	UBERON:0002372	93.46	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.30	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.10	gold quality
lower esophagus mucosa	UBERON:0035834	89.13	gold quality
blood	UBERON:0000178	89.01	gold quality
liver	UBERON:0002107	88.26	gold quality
skeletal muscle tissue	UBERON:0001134	88.20	gold quality
adrenal tissue	UBERON:0018303	87.28	gold quality
monocyte	CL:0000576	87.14	gold quality
prefrontal cortex	UBERON:0000451	87.08	gold quality
leukocyte	CL:0000738	86.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	86.02	gold quality
bone marrow	UBERON:0002371	86.01	gold quality
ventricular zone	UBERON:0003053	85.67	gold quality
kidney	UBERON:0002113	84.47	gold quality
right lobe of liver	UBERON:0001114	84.28	gold quality
adult mammalian kidney	UBERON:0000082	83.82	gold quality
primary visual cortex	UBERON:0002436	83.50	gold quality
urinary bladder	UBERON:0001255	82.58	gold quality
granulocyte	CL:0000094	82.37	gold quality
calcaneal tendon	UBERON:0003701	81.75	gold quality
uterine cervix	UBERON:0000002	80.97	gold quality
thoracic mammary gland	UBERON:0005200	80.95	gold quality
cortex of kidney	UBERON:0001225	80.77	gold quality
tibial nerve	UBERON:0001323	80.75	gold quality
right testis	UBERON:0004534	80.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-3648 Promotes Prostate Cancer Cell Proliferation by Inhibiting Adenomatous Polyposis Coli 2. (PMID:31196256)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR3648-1 (ENSG00000275708)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.