MIR3649

Summary

MIR3649 (microRNA 3649, HGNC:38948) is a microRNA gene on chromosome 12p13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500816 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38948
Approved symbol	MIR3649
Name	microRNA 3649
Location	12p13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3649
Ensembl gene	ENSG00000266043
Ensembl biotype	miRNA
Entrez	100500816
RNAcentral	URS000075BB44 — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577921

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577921 — 1 exons

Exon	Start	End
ENSE00002719684	1660315	1660380

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 90.79.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	90.79	gold quality
bone marrow	UBERON:0002371	81.13	gold quality
right lobe of liver	UBERON:0001114	79.14	gold quality
rectum	UBERON:0001052	78.35	gold quality
myometrium	UBERON:0001296	77.58	gold quality
liver	UBERON:0002107	77.04	gold quality
prefrontal cortex	UBERON:0000451	76.57	gold quality
muscle of leg	UBERON:0001383	75.79	gold quality
blood	UBERON:0000178	75.26	gold quality
gastrocnemius	UBERON:0001388	75.09	gold quality
lymph node	UBERON:0000029	73.60	gold quality
islet of Langerhans	UBERON:0000006	71.75	gold quality
body of pancreas	UBERON:0001150	70.87	gold quality
heart left ventricle	UBERON:0002084	70.58	gold quality
tibial artery	UBERON:0007610	70.43	gold quality
body of stomach	UBERON:0001161	69.88	gold quality
body of uterus	UBERON:0009853	69.76	gold quality
stomach	UBERON:0000945	69.67	gold quality
thoracic mammary gland	UBERON:0005200	69.55	gold quality
heart	UBERON:0000948	69.45	gold quality
putamen	UBERON:0001874	69.20	gold quality
endometrium	UBERON:0001295	68.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.62	gold quality
intestine	UBERON:0000160	68.58	gold quality
transverse colon	UBERON:0001157	68.40	gold quality
small intestine	UBERON:0002108	68.24	gold quality
colon	UBERON:0001155	68.10	gold quality
left adrenal gland	UBERON:0001234	67.97	gold quality
Ammon’s horn	UBERON:0001954	67.90	gold quality
adipose tissue	UBERON:0001013	67.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.