MIR3650

Summary

MIR3650 (microRNA 3650, HGNC:38981) is a microRNA gene on chromosome 5p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500824 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38981
Approved symbol	MIR3650
Name	microRNA 3650
Location	5p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3650
Ensembl gene	ENSG00000265304
Ensembl biotype	miRNA
Entrez	100500824
RNAcentral	URS000075A656 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581972

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581972 — 1 exons

Exon	Start	End
ENSE00002734159	38557502	38557561

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 70.33.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	70.33	gold quality
body of stomach	UBERON:0001161	67.44	gold quality
gastrocnemius	UBERON:0001388	66.91	gold quality
hypothalamus	UBERON:0001898	66.80	gold quality
skin of leg	UBERON:0001511	66.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.70	gold quality
heart left ventricle	UBERON:0002084	63.24	gold quality
transverse colon	UBERON:0001157	62.77	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.16	gold quality
ascending aorta	UBERON:0001496	58.54	gold quality
esophagus mucosa	UBERON:0002469	58.33	gold quality
right atrium auricular region	UBERON:0006631	56.57	gold quality
omental fat pad	UBERON:0010414	52.86	gold quality
subcutaneous adipose tissue	UBERON:0002190	52.79	gold quality
upper lobe of left lung	UBERON:0008952	48.73	gold quality
skin of abdomen	UBERON:0001416	48.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• our findings are the first time to demonstrate that reduced expression of miR-3650 in hepatocellular carcinoma (HCC) was correlated with tumor metastasis and poor survival. MiR-3650 repressed HCC migration and EMT by directly targeting NFASC. (PMID:31163018)
• MicroRNA3650 Promotes Gastric Cancer Proliferation and Migration through the PTEN/PI3K-AKT-mTOR and Hippo Pathways. (PMID:38031771)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.