MIR3651

Summary

MIR3651 (microRNA 3651, HGNC:38897) is a microRNA gene on chromosome 9q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500918 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38897
Approved symbol	MIR3651
Name	microRNA 3651
Location	9q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3651
Ensembl gene	ENSG00000281156
Ensembl biotype	miRNA
Entrez	100500918
RNAcentral	URS000075DEE5 — ncRNA, 90 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000630427

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000630427 — 1 exons

Exon	Start	End
ENSE00003769547	92292458	92292547

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 94.94.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.94	gold quality
adrenal tissue	UBERON:0018303	87.14	gold quality
blood	UBERON:0000178	79.46	gold quality
bone marrow	UBERON:0002371	78.37	gold quality
right lobe of liver	UBERON:0001114	75.28	gold quality
islet of Langerhans	UBERON:0000006	74.12	gold quality
adult mammalian kidney	UBERON:0000082	73.39	gold quality
endometrium	UBERON:0001295	73.04	gold quality
gastrocnemius	UBERON:0001388	72.02	gold quality
heart	UBERON:0000948	71.30	gold quality
heart left ventricle	UBERON:0002084	70.74	gold quality
stomach	UBERON:0000945	70.66	gold quality
body of stomach	UBERON:0001161	70.20	gold quality
right atrium auricular region	UBERON:0006631	69.98	gold quality
body of pancreas	UBERON:0001150	69.66	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.27	gold quality
myometrium	UBERON:0001296	68.97	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.37	gold quality
left coronary artery	UBERON:0001626	68.32	gold quality
tonsil	UBERON:0002372	68.13	gold quality
lung	UBERON:0002048	68.00	gold quality
tibial artery	UBERON:0007610	67.83	gold quality
fundus of stomach	UBERON:0001160	67.20	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.08	gold quality
right adrenal gland	UBERON:0001233	67.00	gold quality
left adrenal gland cortex	UBERON:0035825	66.78	gold quality
left adrenal gland	UBERON:0001234	66.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.62	gold quality
transverse colon	UBERON:0001157	66.44	gold quality
saliva-secreting gland	UBERON:0001044	66.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Aberrant expression levels of miR-186, miR-494 and miR-3651 in whole blood samples of oral squamous cell carcinoma are associated with malignancy. (PMID:24452363)
• The miR-3651 expression was significantly down-regulated in tumor tissues compared with the paracancerous tissues, was negatively correlated with neoplasm stage, and was inversely correlated with the overall survival. (PMID:26210449)
• Altered expression of miR-494, miR-3651 and miR-186 appears to be associated with the recurrence of oral squamous cell carcinoma (OSCC). The present study may form the basis for establishing a blood test as a minimally invasive method for the detection of the recurrence of OSCC. (PMID:28498442)
• MicroRNA3651 promotes colorectal cancer cell proliferation through directly repressing Tbox transcription factor 1. (PMID:31922246)
• Hsa-miR-3651 could serve as a novel predictor for in-breast recurrence via FRMD3. (PMID:34865205)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.