MIR3657

Summary

MIR3657 (microRNA 3657, HGNC:38906) is a microRNA gene on chromosome 12q24.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500889 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38906
Approved symbol	MIR3657
Name	microRNA 3657
Location	12q24.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3657
Ensembl gene	ENSG00000266370
Ensembl biotype	miRNA
Entrez	100500889
RNAcentral	URS000075B6BC — miRNA, 117 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584818

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584818 — 1 exons

Exon	Start	End
ENSE00002710081	112037599	112037715

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 79.82.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	79.82	gold quality
monocyte	CL:0000576	79.62	gold quality
apex of heart	UBERON:0002098	77.87	gold quality
blood	UBERON:0000178	75.35	gold quality
right coronary artery	UBERON:0001625	74.84	gold quality
muscle of leg	UBERON:0001383	74.42	gold quality
gastrocnemius	UBERON:0001388	74.42	gold quality
islet of Langerhans	UBERON:0000006	74.25	gold quality
calcaneal tendon	UBERON:0003701	73.28	gold quality
smooth muscle tissue	UBERON:0001135	73.13	gold quality
adrenal tissue	UBERON:0018303	72.86	gold quality
left uterine tube	UBERON:0001303	72.81	gold quality
right adrenal gland	UBERON:0001233	72.69	gold quality
lymph node	UBERON:0000029	71.79	gold quality
endometrium	UBERON:0001295	71.54	gold quality
ectocervix	UBERON:0012249	71.29	gold quality
bone marrow	UBERON:0002371	71.23	gold quality
liver	UBERON:0002107	71.08	gold quality
stomach	UBERON:0000945	71.04	gold quality
left ovary	UBERON:0002119	70.87	gold quality
body of uterus	UBERON:0009853	70.72	gold quality
heart	UBERON:0000948	70.65	gold quality
myometrium	UBERON:0001296	70.32	gold quality
right atrium auricular region	UBERON:0006631	70.20	gold quality
tibial artery	UBERON:0007610	70.20	gold quality
popliteal artery	UBERON:0002250	70.18	gold quality
body of pancreas	UBERON:0001150	70.16	gold quality
thoracic mammary gland	UBERON:0005200	70.10	gold quality
thoracic aorta	UBERON:0001515	69.92	gold quality
ascending aorta	UBERON:0001496	69.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.