MIR3658

Summary

MIR3658 (microRNA 3658, HGNC:38963) is a microRNA gene on chromosome 1q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500832 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38963
Approved symbol	MIR3658
Name	microRNA 3658
Location	1q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3658
Ensembl gene	ENSG00000283936
Ensembl biotype	miRNA
Entrez	100500832
RNAcentral	URS000075BCB3 — ncRNA, 56 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636291

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636291 — 1 exons

Exon	Start	End
ENSE00003798050	165907921	165907976

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 66.87.

Top tissues by expression

1 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	66.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-3658 overexpression is involved in tumor progression of bladder cancer, indicating that the miRNA possesses prognostic values. (PMID:27820650)
• Data indicate that miR-3658 regulates tumor biological behavior and its downstream molecule signaling pathways through longevity assurance 2 protein (LASS2). (PMID:29739079)
• Hsa-miR-3658 down-regulates OCT4 gene expression followed by suppressing SW480 cell proliferation and migration. (PMID:32478824)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.