MIR3659

Summary

MIR3659 (microRNA 3659, HGNC:38882) is a microRNA gene on chromosome 1p34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500801 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38882
Approved symbol	MIR3659
Name	microRNA 3659
Location	1p34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3659
Ensembl gene	ENSG00000265596
Ensembl biotype	miRNA
Entrez	100500801
RNAcentral	URS000075A969 — miRNA, 99 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582606

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582606 — 1 exons

Exon	Start	End
ENSE00002707188	38089231	38089329

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 77.49.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	77.49	gold quality
blood	UBERON:0000178	75.88	gold quality
skin of abdomen	UBERON:0001416	72.23	gold quality
heart left ventricle	UBERON:0002084	72.19	gold quality
lung	UBERON:0002048	72.15	gold quality
body of stomach	UBERON:0001161	71.80	gold quality
kidney	UBERON:0002113	71.59	gold quality
gastrocnemius	UBERON:0001388	71.49	gold quality
zone of skin	UBERON:0000014	71.31	gold quality
intestine	UBERON:0000160	71.04	gold quality
left adrenal gland cortex	UBERON:0035825	71.02	gold quality
skin of leg	UBERON:0001511	70.49	gold quality
body of pancreas	UBERON:0001150	70.40	gold quality
myometrium	UBERON:0001296	69.63	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.45	gold quality
left adrenal gland	UBERON:0001234	69.33	gold quality
nucleus accumbens	UBERON:0001882	68.73	gold quality
tibial artery	UBERON:0007610	68.44	gold quality
transverse colon	UBERON:0001157	68.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.19	gold quality
vagina	UBERON:0000996	68.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.33	gold quality
left lobe of thyroid gland	UBERON:0001120	66.79	gold quality
body of uterus	UBERON:0009853	66.68	gold quality
left ovary	UBERON:0002119	66.50	gold quality
esophagus mucosa	UBERON:0002469	66.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.30	gold quality
minor salivary gland	UBERON:0001830	65.11	gold quality
ascending aorta	UBERON:0001496	65.02	gold quality
prostate gland	UBERON:0002367	64.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity. (PMID:30642348)
• TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659. (PMID:34328265)
• Urinary hsv2-miR-H9 to hsa-miR-3659 ratio is an effective marker for discriminating prostate cancer from benign prostate hyperplasia in patients within the prostate-specific antigen grey zone. (PMID:35244999)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.