MIR3660

Summary

MIR3660 (microRNA 3660, HGNC:38985) is a microRNA gene on chromosome 5q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500825 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38985
Approved symbol	MIR3660
Name	microRNA 3660
Location	5q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3660
Ensembl gene	ENSG00000264342
Ensembl biotype	miRNA
Entrez	100500825
RNAcentral	URS000075DE65 — miRNA, 100 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584845

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584845 — 1 exons

Exon	Start	End
ENSE00002711639	90016621	90016720

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 91.91.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.91	gold quality
calcaneal tendon	UBERON:0003701	81.89	gold quality
monocyte	CL:0000576	78.21	gold quality
endometrium	UBERON:0001295	77.92	gold quality
right atrium auricular region	UBERON:0006631	75.52	gold quality
tibial artery	UBERON:0007610	75.11	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.51	gold quality
hypothalamus	UBERON:0001898	70.74	gold quality
ascending aorta	UBERON:0001496	69.02	gold quality
vagina	UBERON:0000996	68.60	gold quality
omental fat pad	UBERON:0010414	67.65	gold quality
transverse colon	UBERON:0001157	66.75	gold quality
thyroid gland	UBERON:0002046	66.42	gold quality
substantia nigra	UBERON:0002038	66.17	gold quality
pituitary gland	UBERON:0000007	65.76	gold quality
prefrontal cortex	UBERON:0000451	65.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.78	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.89	gold quality
tibial nerve	UBERON:0001323	63.18	gold quality
left uterine tube	UBERON:0001303	63.04	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.53	gold quality
body of uterus	UBERON:0009853	59.90	gold quality
left testis	UBERON:0004533	47.90	gold quality
right testis	UBERON:0004534	47.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.