MIR3661

Summary

MIR3661 (microRNA 3661, HGNC:38892) is a microRNA gene on chromosome 5q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500905 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38892
Approved symbol	MIR3661
Name	microRNA 3661
Location	5q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3661
Ensembl gene	ENSG00000266751
Ensembl biotype	miRNA
Entrez	100500905
RNAcentral	URS0000759DAE — miRNA, 96 nt, 26 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577394

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577394 — 1 exons

Exon	Start	End
ENSE00002720465	134225757	134225852

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 85.23.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.23	gold quality
sural nerve	UBERON:0015488	81.49	gold quality
bone marrow	UBERON:0002371	78.40	gold quality
adrenal tissue	UBERON:0018303	76.86	gold quality
lymph node	UBERON:0000029	76.43	gold quality
kidney	UBERON:0002113	75.43	gold quality
fundus of stomach	UBERON:0001160	75.25	gold quality
muscle of leg	UBERON:0001383	74.87	gold quality
liver	UBERON:0002107	74.60	gold quality
stomach	UBERON:0000945	74.46	gold quality
adult mammalian kidney	UBERON:0000082	74.45	gold quality
gastrocnemius	UBERON:0001388	74.36	gold quality
granulocyte	CL:0000094	74.12	gold quality
islet of Langerhans	UBERON:0000006	73.68	gold quality
endometrium	UBERON:0001295	73.62	gold quality
vagina	UBERON:0000996	73.37	gold quality
monocyte	CL:0000576	71.97	gold quality
heart left ventricle	UBERON:0002084	71.22	gold quality
colon	UBERON:0001155	71.13	gold quality
intestine	UBERON:0000160	70.91	gold quality
left adrenal gland	UBERON:0001234	70.77	gold quality
minor salivary gland	UBERON:0001830	69.95	gold quality
heart	UBERON:0000948	69.94	gold quality
left adrenal gland cortex	UBERON:0035825	69.76	gold quality
right adrenal gland	UBERON:0001233	69.58	gold quality
right atrium auricular region	UBERON:0006631	69.24	gold quality
right lobe of liver	UBERON:0001114	69.20	gold quality
right lobe of thyroid gland	UBERON:0001119	69.15	gold quality
tibial artery	UBERON:0007610	68.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.