MIR3662

Summary

MIR3662 (microRNA 3662, HGNC:38983) is a microRNA gene on chromosome 6q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500880 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38983
Approved symbol	MIR3662
Name	microRNA 3662
Location	6q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3662
Ensembl gene	ENSG00000283409
Ensembl biotype	miRNA
Entrez	100500880
RNAcentral	URS000075BD9F — ncRNA, 95 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637030

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637030 — 1 exons

Exon	Start	End
ENSE00003793775	134979338	134979432

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 89.37.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	89.37	gold quality
bone marrow	UBERON:0002371	87.62	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.94	gold quality
vermiform appendix	UBERON:0001154	83.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	81.01	gold quality
calcaneal tendon	UBERON:0003701	80.25	gold quality
duodenum	UBERON:0002114	78.94	gold quality
substantia nigra	UBERON:0002038	77.77	gold quality
liver	UBERON:0002107	77.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	77.52	gold quality
cerebellar hemisphere	UBERON:0002245	77.41	gold quality
ectocervix	UBERON:0012249	77.25	gold quality
right lobe of liver	UBERON:0001114	77.19	gold quality
endometrium	UBERON:0001295	77.08	gold quality
adrenal tissue	UBERON:0018303	76.92	gold quality
left ovary	UBERON:0002119	76.83	gold quality
tibial nerve	UBERON:0001323	76.76	gold quality
Ammon’s horn	UBERON:0001954	76.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.73	gold quality
monocyte	CL:0000576	76.63	gold quality
myometrium	UBERON:0001296	76.60	gold quality
skin of abdomen	UBERON:0001416	76.20	gold quality
ovary	UBERON:0000992	76.13	gold quality
pancreas	UBERON:0001264	75.94	gold quality
muscle of leg	UBERON:0001383	75.89	gold quality
right atrium auricular region	UBERON:0006631	75.87	gold quality
body of pancreas	UBERON:0001150	75.86	gold quality
apex of heart	UBERON:0002098	75.84	gold quality
gastrocnemius	UBERON:0001388	75.73	gold quality
zone of skin	UBERON:0000014	75.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Expression of miR-944 and miR-3662 was upregulated in patients with lung cancer in comparison with healthy individuals. (PMID:26079400)
• The characterization of miR-3662 has identified a new actor in the prominent hematopoietic quantitative trait locus in chromosome 6q23.3. The mechanistic insights into miR-3662’s function may reveal novel or only partially known pathways for normal and malignant hematopoietic cell proliferation. (PMID:27354268)
• Circulating pri-miRNA-944 and 3662 can improve non-invasive non-small cell lung cancer detection of operable stages of SCC and AC (PMID:28964576)
• miR-3662 was correlated with antiviral drug resistance in adult T-cell leukemia/lymphoma cell lines. (PMID:29684346)
• findings uncover a mechanistic role for miR-3662/HIF-1alpha axis in hepatocellular carcinoma metabolic reprogramming, providing a potential therapeutic strategy in liver cancer. (PMID:29748591)
• MiR-3662 suppresses cell growth, invasion and glucose metabolism by targeting HK2 in hepatocellular carcinoma cells. (PMID:32726127)
• MiRNA-3662 reverses the gemcitabine resistance in pancreatic cancer through regulating the tumor metabolism. (PMID:33993382)
• Detection significance of miR-3662, miR-146a, and miR-1290 in serum exosomes of breast cancer patients. (PMID:34269309)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.