MIR3663

Summary

MIR3663 (microRNA 3663, HGNC:38958) is a microRNA gene on chromosome 10q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500893 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38958
Approved symbol	MIR3663
Name	microRNA 3663
Location	10q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3663
Ensembl gene	ENSG00000266782
Ensembl biotype	miRNA
Entrez	100500893
RNAcentral	URS000075A61D — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583207

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583207 — 1 exons

Exon	Start	End
ENSE00002725007	117167678	117167774

Expression profiles

Bgee: expression breadth broad, 27 present calls, max score 77.67.

Top tissues by expression

27 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	77.67	gold quality
heart	UBERON:0000948	75.93	gold quality
prefrontal cortex	UBERON:0000451	71.20	gold quality
hypothalamus	UBERON:0001898	70.99	gold quality
cerebellar hemisphere	UBERON:0002245	68.43	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.28	gold quality
tibial artery	UBERON:0007610	68.18	gold quality
nucleus accumbens	UBERON:0001882	67.72	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.08	gold quality
adenohypophysis	UBERON:0002196	66.88	gold quality
brain	UBERON:0000955	66.59	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.57	gold quality
substantia nigra	UBERON:0002038	66.45	gold quality
putamen	UBERON:0001874	66.01	gold quality
blood	UBERON:0000178	65.87	gold quality
anterior cingulate cortex	UBERON:0009835	65.75	gold quality
Ammon’s horn	UBERON:0001954	65.03	gold quality
caudate nucleus	UBERON:0001873	64.72	gold quality
right frontal lobe	UBERON:0002810	64.66	gold quality
pituitary gland	UBERON:0000007	64.00	gold quality
amygdala	UBERON:0001876	63.59	gold quality
right testis	UBERON:0004534	63.57	gold quality
vagina	UBERON:0000996	63.56	gold quality
lung	UBERON:0002048	60.01	gold quality
testis	UBERON:0000473	59.10	gold quality
left testis	UBERON:0004533	58.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer. (PMID:31587286)
• MiR-3663-3p Inhibits the Progression of Gastric Cancer Through the CCND1 Pathway. (PMID:33952469)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.