MIR3664

Summary

MIR3664 (microRNA 3664, HGNC:38899) is a microRNA gene on chromosome 11q13.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500844 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38899
Approved symbol	MIR3664
Name	microRNA 3664
Location	11q13.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3664
Ensembl gene	ENSG00000263744
Ensembl biotype	miRNA
Entrez	100500844
RNAcentral	URS000075991E — miRNA, 99 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579074

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579074 — 1 exons

Exon	Start	End
ENSE00002722502	70872270	70872368

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 78.78.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	78.78	gold quality
kidney	UBERON:0002113	77.17	gold quality
right lobe of liver	UBERON:0001114	75.65	gold quality
liver	UBERON:0002107	75.31	gold quality
adult mammalian kidney	UBERON:0000082	74.66	gold quality
stomach	UBERON:0000945	72.23	gold quality
intestine	UBERON:0000160	72.16	gold quality
Ammon’s horn	UBERON:0001954	71.84	gold quality
body of pancreas	UBERON:0001150	71.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.45	gold quality
right lobe of thyroid gland	UBERON:0001119	69.22	gold quality
esophagus mucosa	UBERON:0002469	68.63	gold quality
body of stomach	UBERON:0001161	67.77	gold quality
transverse colon	UBERON:0001157	67.47	gold quality
colon	UBERON:0001155	67.04	gold quality
omental fat pad	UBERON:0010414	66.91	gold quality
right uterine tube	UBERON:0001302	66.79	gold quality
minor salivary gland	UBERON:0001830	66.68	gold quality
skin of abdomen	UBERON:0001416	66.43	gold quality
lung	UBERON:0002048	66.20	gold quality
upper lobe of left lung	UBERON:0008952	65.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.64	gold quality
skin of leg	UBERON:0001511	65.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.36	gold quality
prostate gland	UBERON:0002367	64.10	gold quality
hypothalamus	UBERON:0001898	64.02	gold quality
left lobe of thyroid gland	UBERON:0001120	63.03	gold quality
thyroid gland	UBERON:0002046	62.98	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.56	gold quality
nucleus accumbens	UBERON:0001882	62.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR36645P is downregulated in gastric cancer (GC) tissues and is positively associated with the prognosis of patients with GC. miR36645P knockdown promots the proliferation and metastasis of GC cells in vitro and in vivo. miR36645P reduces metadherin (MTDH) expression and downregulates the nuclear factor (NF)kappaB signaling pathway. miR36645P has potential to be an independent prognostic factor and biomarker in GC. (PMID:30628643)
• Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. (PMID:31235820)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.