MIR3665

Summary

MIR3665 (microRNA 3665, HGNC:38939) is a microRNA gene on chromosome 13q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500861 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38939
Approved symbol	MIR3665
Name	microRNA 3665
Location	13q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3665
Ensembl gene	ENSG00000266325
Ensembl biotype	miRNA
Entrez	100500861
RNAcentral	URS000075E1E9 — ncRNA, 105 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578708

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578708 — 1 exons

Exon	Start	End
ENSE00002684361	77698012	77698116

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 77.91.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	77.91	gold quality
right lobe of liver	UBERON:0001114	77.58	gold quality
blood	UBERON:0000178	77.06	gold quality
gastrocnemius	UBERON:0001388	72.90	gold quality
body of pancreas	UBERON:0001150	72.25	gold quality
lymph node	UBERON:0000029	71.73	gold quality
placenta	UBERON:0001987	71.50	gold quality
adult mammalian kidney	UBERON:0000082	71.49	gold quality
heart left ventricle	UBERON:0002084	71.38	gold quality
putamen	UBERON:0001874	70.29	gold quality
leukocyte	CL:0000738	68.02	gold quality
transverse colon	UBERON:0001157	67.42	gold quality
right atrium auricular region	UBERON:0006631	67.33	gold quality
esophagus mucosa	UBERON:0002469	67.19	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.95	gold quality
minor salivary gland	UBERON:0001830	66.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.53	gold quality
skin of abdomen	UBERON:0001416	66.15	gold quality
left adrenal gland cortex	UBERON:0035825	66.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.93	gold quality
omental fat pad	UBERON:0010414	65.79	gold quality
heart	UBERON:0000948	65.46	gold quality
thoracic aorta	UBERON:0001515	65.38	gold quality
body of stomach	UBERON:0001161	65.24	gold quality
left coronary artery	UBERON:0001626	65.24	gold quality
ascending aorta	UBERON:0001496	64.37	gold quality
spleen	UBERON:0002106	63.91	gold quality
skin of leg	UBERON:0001511	63.37	gold quality
body of uterus	UBERON:0009853	63.29	gold quality
left adrenal gland	UBERON:0001234	63.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A Potential ceRNA Network for Neurological Damage in Preterm Infants. (PMID:34471635)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.