MIR3666

Summary

MIR3666 (microRNA 3666, HGNC:38940) is a microRNA gene on chromosome 7q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500896 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38940
Approved symbol	MIR3666
Name	microRNA 3666
Location	7q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3666
Ensembl gene	ENSG00000272230
Ensembl biotype	miRNA
Entrez	100500896
RNAcentral	URS000075CD54 — ncRNA, 111 nt, 30 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000607845

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000607845 — 1 exons

Exon	Start	End
ENSE00003695131	114653345	114653455

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 80.32.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.32	gold quality
monocyte	CL:0000576	80.23	gold quality
calcaneal tendon	UBERON:0003701	80.20	gold quality
stomach	UBERON:0000945	80.07	gold quality
adrenal tissue	UBERON:0018303	78.50	gold quality
ectocervix	UBERON:0012249	77.08	gold quality
islet of Langerhans	UBERON:0000006	74.58	gold quality
gastrocnemius	UBERON:0001388	74.32	gold quality
ascending aorta	UBERON:0001496	73.25	gold quality
thoracic aorta	UBERON:0001515	72.88	gold quality
lung	UBERON:0002048	72.70	gold quality
right ovary	UBERON:0002118	72.52	gold quality
liver	UBERON:0002107	72.40	gold quality
body of uterus	UBERON:0009853	72.26	gold quality
right lobe of liver	UBERON:0001114	72.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.75	gold quality
left coronary artery	UBERON:0001626	70.72	gold quality
body of stomach	UBERON:0001161	70.56	gold quality
vagina	UBERON:0000996	70.47	gold quality
endocervix	UBERON:0000458	70.46	gold quality
intestine	UBERON:0000160	70.35	gold quality
colon	UBERON:0001155	70.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.25	gold quality
myometrium	UBERON:0001296	70.23	gold quality
heart	UBERON:0000948	70.14	gold quality
esophagus mucosa	UBERON:0002469	70.09	gold quality
blood	UBERON:0000178	70.06	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.88	gold quality
descending thoracic aorta	UBERON:0002345	69.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Results show that reduced miR-3666 levels in thyroid carcinoma tissue may promotes its growth, possibly through MET-mediated cell proliferation. (PMID:26937629)
• our study suggests that SIRT7 functions as an oncogene in non-small cell lung cancer (NSCLC), and miR-3666 can target SIRT7 to inhibit NSCLC cell growth by promoting the pro-apoptotic signaling pathway (PMID:27599551)
• miR-3666 is an important regulator of breast cancer development. The overexpression of miR-3666 inhibits breast cancer cell proliferation by inhibiting SIRT7. (PMID:28944911)
• MiR-3666/E2F7 may play a key role in regulating the inhibitory effects of ATRA on HCT116 cells. (PMID:29772445)
• miR-3666 was reported to be downregulated in CRC tissues and overexpression of miR-3666 impaired the proliferation, migration and invasion of CRC cells by targeting SATB2 in the present study. (PMID:30320357)
• data indicate that miR-3666 could play an essential role in cell proliferation, migration, and invasiveness by targeting BPTF and partly inhibiting the PI3K-AKT and EMT signaling pathways in human lung cancers (PMID:30481052)
• MicroRNA3666 suppresses the growth and migration of glioblastoma cells by targeting KDM2A. (PMID:30483744)
• LncRNA NNT-AS1 regulates the progression of lung cancer through the NNT-AS1/miR-3666/E2F2 axis. (PMID:31957837)
• Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666. (PMID:32017171)
• miR-3666 inhibits development of hepatic steatosis by negatively regulating PPARgamma. (PMID:32755726)
• MiR-3666 serves as a tumor suppressor in ovarian carcinoma by down-regulating AK4 via targeting STAT3. (PMID:33361582)
• [Effects of LINC00839 targeting miR-3666 on proliferation, migration and invasion of hepatocellular carcinoma cells]. (PMID:34794216)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.