MIR3667

Summary

MIR3667 (microRNA 3667, HGNC:38990) is a microRNA gene on chromosome 22q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500882 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38990
Approved symbol	MIR3667
Name	microRNA 3667
Location	22q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3667
Ensembl gene	ENSG00000264139
Ensembl biotype	miRNA
Entrez	100500882
RNAcentral	URS000075EBAC — ncRNA, 74 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581025

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581025 — 1 exons

Exon	Start	End
ENSE00002716121	49543393	49543466

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 80.98.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	80.98	gold quality
ovary	UBERON:0000992	76.60	gold quality
blood	UBERON:0000178	74.24	gold quality
gastrocnemius	UBERON:0001388	74.07	gold quality
monocyte	CL:0000576	72.86	gold quality
endometrium	UBERON:0001295	71.70	gold quality
heart left ventricle	UBERON:0002084	70.21	gold quality
anterior cingulate cortex	UBERON:0009835	69.27	gold quality
right coronary artery	UBERON:0001625	67.34	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.17	gold quality
body of stomach	UBERON:0001161	67.03	gold quality
tibial artery	UBERON:0007610	66.59	gold quality
granulocyte	CL:0000094	66.56	gold quality
Ammon’s horn	UBERON:0001954	66.20	gold quality
descending thoracic aorta	UBERON:0002345	65.92	gold quality
right atrium auricular region	UBERON:0006631	65.89	gold quality
minor salivary gland	UBERON:0001830	65.84	gold quality
lung	UBERON:0002048	65.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.45	gold quality
skin of abdomen	UBERON:0001416	65.44	gold quality
substantia nigra	UBERON:0002038	64.91	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.82	gold quality
omental fat pad	UBERON:0010414	64.71	gold quality
upper lobe of left lung	UBERON:0008952	64.64	gold quality
esophagus mucosa	UBERON:0002469	64.61	gold quality
left adrenal gland cortex	UBERON:0035825	64.03	gold quality
thoracic mammary gland	UBERON:0005200	63.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.93	gold quality
transverse colon	UBERON:0001157	63.82	gold quality
skin of leg	UBERON:0001511	63.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Through conducting multivariate analysis in the training test, it was identified that the high expression of hsa-miR-509 and hsa-miR-542 were independent poor prognostic factors, whereas that of hsa-miR-146a and hsa-miR-3667 had a trend to be favorable factors. A 4-miRNA signature was constructed by these miRNAs considering the weight of each. (PMID:30242879)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.