MIR3668

Summary

MIR3668 (microRNA 3668, HGNC:38982) is a microRNA gene on chromosome 6q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500879 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38982
Approved symbol	MIR3668
Name	microRNA 3668
Location	6q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3668
Ensembl gene	ENSG00000263514
Ensembl biotype	miRNA
Entrez	100500879
RNAcentral	URS000075ACA8 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582138

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582138 — 1 exons

Exon	Start	End
ENSE00002704746	140205252	140205326

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 76.75.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	76.75	gold quality
blood	UBERON:0000178	69.00	gold quality
Ammon’s horn	UBERON:0001954	66.31	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.89	gold quality
tibial nerve	UBERON:0001323	63.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.22	gold quality
ascending aorta	UBERON:0001496	60.84	gold quality
left lobe of thyroid gland	UBERON:0001120	60.33	gold quality
thyroid gland	UBERON:0002046	60.17	gold quality
fallopian tube	UBERON:0003889	59.69	gold quality
thoracic mammary gland	UBERON:0005200	52.81	gold quality
colon	UBERON:0001155	46.78	gold quality
testis	UBERON:0000473	45.78	gold quality
left testis	UBERON:0004533	44.55	gold quality
right testis	UBERON:0004534	40.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.