MIR3670-2

Summary

MIR3670-2 (microRNA 3670-2, HGNC:43460) is a microRNA gene on chromosome 16p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100846994 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43460
Approved symbol	MIR3670-2
Name	microRNA 3670-2
Location	16p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3670-2
Ensembl gene	ENSG00000264722
Ensembl biotype	miRNA
Entrez	100846994
RNAcentral	URS000075B9CE — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582974

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582974 — 1 exons

Exon	Start	End
ENSE00002699985	16306370	16306434

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 87.40.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.40	gold quality
bone marrow	UBERON:0002371	71.80	gold quality
monocyte	CL:0000576	66.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.94	gold quality
lower esophagus mucosa	UBERON:0035834	64.11	gold quality
gastrocnemius	UBERON:0001388	63.02	gold quality
muscle of leg	UBERON:0001383	62.96	gold quality
blood	UBERON:0000178	62.75	gold quality
islet of Langerhans	UBERON:0000006	62.33	gold quality
left uterine tube	UBERON:0001303	61.23	gold quality
adrenal tissue	UBERON:0018303	60.79	gold quality
stomach	UBERON:0000945	60.56	gold quality
right lobe of thyroid gland	UBERON:0001119	60.55	gold quality
body of stomach	UBERON:0001161	60.14	gold quality
body of pancreas	UBERON:0001150	59.80	gold quality
urinary bladder	UBERON:0001255	59.61	gold quality
liver	UBERON:0002107	59.61	gold quality
heart left ventricle	UBERON:0002084	59.49	gold quality
right lobe of liver	UBERON:0001114	58.09	gold quality
rectum	UBERON:0001052	57.97	gold quality
popliteal artery	UBERON:0002250	57.82	gold quality
tibial artery	UBERON:0007610	57.67	gold quality
heart	UBERON:0000948	57.25	gold quality
calcaneal tendon	UBERON:0003701	57.24	gold quality
right atrium auricular region	UBERON:0006631	56.42	gold quality
lung	UBERON:0002048	56.21	gold quality
gall bladder	UBERON:0002110	55.87	gold quality
right lung	UBERON:0002167	55.71	gold quality
left coronary artery	UBERON:0001626	55.41	gold quality
thoracic aorta	UBERON:0001515	55.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR3670-1 (ENSG00000263918), MIR3670-3 (ENSG00000265776), MIR3670-4 (ENSG00000274025)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.