MIR3674

Summary

MIR3674 (microRNA 3674, HGNC:38915) is a microRNA gene on chromosome 8p23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500912 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38915
Approved symbol	MIR3674
Name	microRNA 3674
Location	8p23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3674
Ensembl gene	ENSG00000283858
Ensembl biotype	miRNA
Entrez	100500912
RNAcentral	URS000075E85D — ncRNA, 68 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636576

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636576 — 1 exons

Exon	Start	End
ENSE00003792657	1801125	1801192

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 72.34.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	72.34	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.63	gold quality
blood	UBERON:0000178	66.97	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.63	gold quality
heart left ventricle	UBERON:0002084	65.46	gold quality
substantia nigra	UBERON:0002038	63.94	gold quality
skin of leg	UBERON:0001511	62.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	57.79	gold quality
tibial artery	UBERON:0007610	55.14	gold quality
upper lobe of left lung	UBERON:0008952	55.12	gold quality
skin of abdomen	UBERON:0001416	47.29	gold quality
anterior cingulate cortex	UBERON:0009835	43.34	gold quality
left testis	UBERON:0004533	34.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.