MIR3675

Summary

MIR3675 (microRNA 3675, HGNC:38973) is a microRNA gene on chromosome 1p36.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500876 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38973
Approved symbol	MIR3675
Name	microRNA 3675
Location	1p36.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3675
Ensembl gene	ENSG00000263811
Ensembl biotype	miRNA
Entrez	100500876
RNAcentral	URS000075BA0D — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583661

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583661 — 1 exons

Exon	Start	End
ENSE00002699344	16858949	16859021

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 93.32.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	93.32	gold quality
stomach	UBERON:0000945	85.41	gold quality
kidney	UBERON:0002113	78.80	gold quality
heart	UBERON:0000948	76.62	gold quality
blood	UBERON:0000178	76.43	gold quality
muscle of leg	UBERON:0001383	75.65	gold quality
monocyte	CL:0000576	73.99	gold quality
gastrocnemius	UBERON:0001388	73.15	gold quality
calcaneal tendon	UBERON:0003701	70.86	gold quality
endometrium	UBERON:0001295	69.55	gold quality
heart left ventricle	UBERON:0002084	69.43	gold quality
right lobe of liver	UBERON:0001114	68.89	gold quality
body of pancreas	UBERON:0001150	68.82	gold quality
lung	UBERON:0002048	68.50	gold quality
transverse colon	UBERON:0001157	66.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.73	gold quality
ascending aorta	UBERON:0001496	66.52	gold quality
left adrenal gland	UBERON:0001234	65.04	gold quality
tibial artery	UBERON:0007610	64.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.28	gold quality
nucleus accumbens	UBERON:0001882	63.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.73	gold quality
right frontal lobe	UBERON:0002810	63.70	gold quality
body of uterus	UBERON:0009853	63.56	gold quality
caudate nucleus	UBERON:0001873	63.36	gold quality
skin of leg	UBERON:0001511	63.34	gold quality
intestine	UBERON:0000160	62.96	gold quality
omental fat pad	UBERON:0010414	62.60	gold quality
cerebellar hemisphere	UBERON:0002245	62.24	gold quality
upper lobe of left lung	UBERON:0008952	61.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.