MIR3677

Summary

MIR3677 (microRNA 3677, HGNC:38932) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500812 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38932
Approved symbol	MIR3677
Name	microRNA 3677
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3677
Ensembl gene	ENSG00000266643
Ensembl biotype	miRNA
Entrez	100500812
RNAcentral	URS000075A213 — ncRNA, 60 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578964

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578964 — 1 exons

Exon	Start	End
ENSE00002723524	2270713	2270772

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 97.60.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.60	gold quality
vermiform appendix	UBERON:0001154	87.64	gold quality
skeletal muscle tissue	UBERON:0001134	86.41	gold quality
upper lobe of left lung	UBERON:0008952	86.16	gold quality
lung	UBERON:0002048	85.74	gold quality
duodenum	UBERON:0002114	85.42	gold quality
right coronary artery	UBERON:0001625	85.12	gold quality
placenta	UBERON:0001987	84.79	gold quality
adrenal tissue	UBERON:0018303	84.67	gold quality
granulocyte	CL:0000094	83.30	gold quality
endometrium	UBERON:0001295	82.05	gold quality
blood	UBERON:0000178	81.87	gold quality
right lung	UBERON:0002167	80.91	gold quality
cerebellar hemisphere	UBERON:0002245	80.37	gold quality
Brodmann (1909) area 9	UBERON:0013540	80.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.23	gold quality
smooth muscle tissue	UBERON:0001135	79.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.23	gold quality
prefrontal cortex	UBERON:0000451	78.71	gold quality
lymph node	UBERON:0000029	78.49	gold quality
cerebral cortex	UBERON:0000956	78.21	gold quality
right uterine tube	UBERON:0001302	78.07	gold quality
frontal cortex	UBERON:0001870	77.93	gold quality
right frontal lobe	UBERON:0002810	77.93	gold quality
fundus of stomach	UBERON:0001160	77.79	gold quality
anterior cingulate cortex	UBERON:0009835	77.76	gold quality
monocyte	CL:0000576	77.29	gold quality
urinary bladder	UBERON:0001255	76.76	gold quality
Ammon’s horn	UBERON:0001954	76.74	gold quality
muscle of leg	UBERON:0001383	76.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Gastric antral vascular ectasia in liver cirrhosis is associated with increased expression of miR-3667 maybe linked with ANGPTL4 gene. (PMID:30621516)
• The therapeutic value of the SphK1-targeting microRNA-3677 in human osteosarcoma cells. (PMID:32203055)
• Hypoxia-induced miR-3677-3p promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by suppressing SIRT5. (PMID:32596968)
• miR-3677-3p promotes hepatocellular carcinoma progression via inhibiting GSK3beta. (PMID:33200777)
• IncRNA TRAF3IP2-AS1 Restrains Cervical Cancer Progression by Sponging miR-3677-3p and Acts As a Diagnostic Marker in Cervical Cancer. (PMID:36374810)
• MiR-3677-3p promotes development and sorafenib resistance of hepatitis B-related hepatocellular carcinoma by inhibiting FOXM1 ubiquitination. (PMID:37402927)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.